Desoxycorticosterone pivalate is a mineralocorticoid hormone and an analog of desoxycorticosterone. It is white, odorless, and stable in air. It is practically insoluble in water, sparingly soluble in acetone, slightly... Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
- Mechanism
- Curator reviewed
Desoxycorticosterone Pivalate binds to the mineralocorticoid receptor. Mineralocorticoids are a family of steroids, secreted by the adrenal cortex, necessary for the regulation of a number of metabolic processes including electrolyte regulation. Desoxycorticosterone pivalate exerts its effect through its interaction with the mineralocorticoid receptor (MR), whereby it reacts with the receptor proteins to form a steroid-receptor complex. This complex moves into the nucleus, where it binds to chromatin which results in genetic transcription of cellular DNA to messenger RNA. The steroid hormones appear to induce transcription and synthesis of specific proteins, which produce the physiological effects seen after administration.
- Primary indication
- Examined for treatment of adrenocortical insufficiency especially in multiple sclerosis, congenital cerebral palsy, polyarteritis nodosa, and rheumatoid arthritis.Curator reviewed
- Formula / weight
- C26H38O4 · 414.586 g/mol (avg)
- Also known as
- Deoxycorticosterone pivalate · Deoxycorticosterone trimethylacetate · Deoxycortone pivalate · Deoxycortone trimethylacetate · Desoxycorticosterone trimethylacetate
Resolves to
VVOIQBFMTVCINR-WWMZEODYSA-NSMILES[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)C(=O)COC(=O)C(C)(C)CWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Desoxycorticosterone pivalate, and which of those have an active Phase 3 trial?
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