Fosamprenavir is an antiretroviral agent used for the treatment and postexposure prophylaxis of human immunodeficiency virus (HIV-1) infection. A medication used to treat HIV infections.
- Mechanism
- Curator reviewed
Fosamprenavir is a prodrug that is rapidly hydrolyzed to amprenavir by cellular phosphatases in the gut epithelium as it is absorbed. Amprenavir is an inhibitor of HIV-1 protease. During HIV replication, HIV protease cleaves viral polypeptide products of the Gag and Gag-Pol genes to form structural proteins of the virion core and essential viral enzymes. Amprenavir interferes with this process by binding to the active site of HIV-1 protease, thereby preventing the processing of viral Gag and Gag-Pol polyprotein precursors, resulting in the formation of immature non-infectious viral particles.
- Primary indication
- Indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV-1) infection, as well as postexposure prophylaxis of HIV infection in individuals who have had occupational or nonoccupational exposure to potentially...Curator reviewed · 1 structured indication
- Formula / weight
- C25H36N3O9PS · 585.607 g/mol (avg)
- First approval
- Canada, 2009 · United States, 2003
- Also known as
- FOS-APV
- Code names
- GW-433908
- Brand names
Resolves to
MLBVMOWEQCZNCC-OEMFJLHTSA-NSMILESCC(C)CN(C[C@@H](OP(O)(O)=O)[C@H](CC1=CC=CC=C1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)C1=CC=C(N)C=C1What you can answer from here — as of September 13, 2026
Which drugs share a target with Fosamprenavir, and which of those have an active Phase 3 trial?
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