Gag-Pol polyprotein

BE0002050ProteinHuman immunodeficiency virus type 1 group M subtype B (isolate HXB2)gag-pol

Gag-Pol polyprotein Mediates, with Gag polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic... It is acted on by 123 drugs in DrugBank.

Gene name
gag-pol
UniProtKB entry
P03366Swiss-Prot
Cellular location
Host cell membrane
Residues / weight
1,447 residues · 163,288 Da
Also known as
Pr160Gag-Pol

Resolves to

Protein
UniProtP03366UniProt namePOL_HV1B1
Gene
GenBank326388
Structure
PDB1A9MPDB1AJVPDB1AJX
Drugs

What you can answer from here — as of February 03, 2025

123DrugsApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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10Pfam domainsDomain architecture mapped to Pfam families and clans
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214+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gag-Pol polyprotein, how selective are they, and which programs against it are still in active trials?

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