Ethylmorphine is an opioid analgesic and antitussive agent used to reduce coughs caused by colds and lung infections in combination with codeine. It is metabolized in the liver by ethylmorphine-N-demethylase and used as an indicator of liver function.
- Mechanism
- Curator reviewed
Ethylmorphine is metabolized by the liver enzyme cytochrome P450 2D6 to morphine. The precise mechanism of the analgesic action of morphine is unknown. However, specific CNS opiate receptors have been identified and likely play a role in the expression of analgesic effects. Morphine first acts on the mu-opioid receptors. The mechanism of respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation. It has been shown that morphine binds to and inhibits GABA inhibitory interneurons. These interneurons normally inhibit the descending pain inhibition pathway. So, without the inhibitory signals, pain modulation can proceed downstream.
- Primary indication
- Ethylmorphine is an analgesic used for pain relief.Curator reviewed · 2 structured indications
- Formula / weight
- C19H23NO3 · 313.3908 g/mol (avg)
- Also known as
- 3-ethoxymorphine · Dionine
- Code names
- DEA No. 9190 · IDS-NE-005(SECT.2)
Resolves to
OGDVEMNWJVYAJL-LEPYJNQMSA-NSMILES[H][C@@]12OC3=C(OCC)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])C=C[C@@H]2OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Ethylmorphine, and which of those have an active Phase 3 trial?
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