1-Testosterone

DB01481IllicitInvestigationalSmall molecule

1-Testosterone is an anabolic steroid that differs from testosterone by having a 1,2-double bond instead of 4,5-double bond in its A ring.

Mechanism: Delta1-dihydrotestosterone binds to the androgen receptor, a nuclear receptor which binds the androgenic hormones testosterone and dihydrotestosterone. Once bound, the receptor/ligand complex localizes to the nucleus and acts as a DNA binding transcription factor, regulating gene expression.
Curator reviewed
Formula / weight: C₁₉H₂₈O₂ · 288.4244 g/mol (avg)
Also known as: 1-Testo · Androstendolone
Code names: J108.132B

Resolves to

Compound

Structure

InChIKeyOKJCFMUGMSVJBG-ABEVXSGRSA-NSMILES[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)C=C[C@]12C

Targets

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

147Drug interactionsStructured to mechanism, not free text

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with 1-Testosterone, and which of those have an active Phase 3 trial?

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