Periciazine is a phenothiazine used with other medications to treat aggressiveness, impulsiveness, and hostility associated with psychiatric conditions such as schizophrenia. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected.
- Mechanism
- Curator reviewed
Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade of the alpha adrenergic receptors as well as antagonism of the D(1) dopamine receptor.
- Primary indication
- For use as adjunctive medication in some psychotic patients.Curator reviewed · 1 structured indication
- Formula / weight
- C21H23N3OS · 365.492 g/mol (avg)
- First approval
- Canada, 2023
- Also known as
- Pericyazine · Piperocyanomazine · Propericiazine
- Code names
- RP-8909 · SKF-20716
- Brand names
Resolves to
LUALIOATIOESLM-UHFFFAOYSA-NSMILESOC1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C#N)CC1What you can answer from here — as of September 19, 2026
Which drugs share a target with Periciazine, and which of those have an active Phase 3 trial?
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