Phenothiazines

Name
Phenothiazines
Accession Number
DBCAT000801
Description

Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.

Drugs
DrugDrug Description
AcepromazineAcepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and...
AceprometazineAceprometazine is often used in combination with meprobamate for the treatment of sleep disorders.
AcetophenazineFor the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions (e.g. hallucinations or delusions.)
AlimemazineAn antihistamine agent used to prevent and relieve allergic conditions which cause pruritus and other allergic skin conditions, including urticaria.
BL-1020Investigated for use/treatment in schizophrenia and schizoaffective disorders.
ButaperazineButaperazine was approved in 1967 , and possibly discontinued in the 1980s .
ChlorproethazineNot Annotated
ChlorpromazineA phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children.
CyamemazineCyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class used primarily in the treatment of schizophrenia and psychosis-associated anxiety. Cyamemazine actually behaves like an...
DixyrazineNot Annotated
FluphenazineA phenothiazine used to treat patients requiring long-term neuroleptic therapy.
Hydromethylthionine mesylateNot Annotated
MesoridazineA phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses.
MethotrimeprazineA phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.
Methylene blueAn oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia.
MoricizineAn antiarrhythmic used to treat arrhythmias.
PerazineA phenothiazine antipsychotic used in the acute and chronic treatment of psychotic disorders.
PericiazineA phenothiazine used with other medications to treat aggressiveness, impulsiveness, and hostility associated with psychiatric conditions such as schizophrenia.
PerphenazineA phenothiazine used to treat schizophrenia as well as nausea and vomiting.
Perphenazine enanthateNot Annotated
PipotiazineAn antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients.
ProchlorperazineA phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting.
PromazineA phenothiazine used to manage schizophrenia.
PromethazineA first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
PropiopromazineNot Annotated
ThiazinamNot Annotated
ThiethylperazineA drug used for the treatment of nausea and vomiting.
ThioproperazineAn antipsychotic indicated for the management of acute and chronic schizophrenia, including cases that are refractory to more common neuroleptics. May also be used to treat manic syndromes.
ThioridazineA phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder.
TrifluoperazineA phenothiazine used to treat depression, anxiety, and agitation.
TriflupromazineUsed mainly in the management of psychoses. Also used to control nausea and vomiting.
Drugs & Drug Targets
DrugTargetType
AcepromazineAlbumincarrier
AcepromazineAlpha-1B adrenergic receptortarget
AcepromazineD(2) dopamine receptortarget
AcepromazineD(1A) dopamine receptortarget
Acepromazine5-hydroxytryptamine receptor 2Atarget
Acepromazine5-hydroxytryptamine receptor 1Atarget
AcepromazineAlpha-1A adrenergic receptortarget
AceprometazineHistamine H1 receptortarget
AcetophenazineAndrogen receptortarget
AcetophenazineD(2) dopamine receptortarget
AlimemazineHistamine H1 receptortarget
BL-10205-hydroxytryptamine receptor 2Atarget
BL-1020D(2) dopamine receptortarget
Chlorpromazine5-hydroxytryptamine receptor 1Atarget
ChlorpromazineAlpha-1A adrenergic receptortarget
ChlorpromazineAlpha-1B adrenergic receptortarget
ChlorpromazineCytochrome P450 2E1enzyme
ChlorpromazineCytochrome P450 3A4enzyme
ChlorpromazineHistamine H1 receptortarget
ChlorpromazineVoltage-gated inwardly rectifying potassium channel KCNH2target
ChlorpromazineD(1) dopamine receptortarget
ChlorpromazineD(3) dopamine receptortarget
ChlorpromazineD(4) dopamine receptortarget
ChlorpromazineD(1B) dopamine receptortarget
ChlorpromazineATP-dependent translocase ABCB1transporter
Chlorpromazine5-hydroxytryptamine 2 receptortarget
ChlorpromazineAlpha-1 adrenergic receptorstarget
ChlorpromazineAlpha-2 adrenergic receptorstarget
ChlorpromazineMuscarinic acetylcholine receptor M1target
ChlorpromazineMuscarinic acetylcholine receptor M3target
ChlorpromazineSphingomyelin phosphodiesterasetarget
Chlorpromazinealpha1-acid glycoproteintarget
Chlorpromazine5-hydroxytryptamine receptor 6target
Chlorpromazine5-hydroxytryptamine receptor 7target
ChlorpromazineHistamine H4 receptortarget
ChlorpromazineBile salt export pumptransporter
ChlorpromazineCalmodulintarget
ChlorpromazineAlbumincarrier
ChlorpromazineCytochrome P450 1A2enzyme
ChlorpromazineCholinesteraseenzyme
ChlorpromazineCytochrome P450 2D6enzyme
Chlorpromazine5-hydroxytryptamine receptor 2Atarget
ChlorpromazineD(2) dopamine receptortarget
Chlorpromazine5-hydroxytryptamine receptor 2Ctarget
ChlorpromazineD(1A) dopamine receptortarget
Cyamemazine5-hydroxytryptamine receptor 7target
Cyamemazine5-hydroxytryptamine receptor 2Ctarget
Cyamemazine5-hydroxytryptamine receptor 1Atarget
Cyamemazine5-hydroxytryptamine receptor 2Atarget
FluphenazineAndrogen receptortarget
FluphenazineCalmodulintarget
Fluphenazine5-hydroxytryptamine receptor 1Btarget
Fluphenazine5-hydroxytryptamine receptor 2Ctarget
Fluphenazine5-hydroxytryptamine receptor 2Atarget
FluphenazineD(2) dopamine receptortarget
FluphenazineD(1A) dopamine receptortarget
FluphenazineCytochrome P450 2D6enzyme
FluphenazineATP-dependent translocase ABCB1transporter
FluphenazineCytochrome P450 2E1enzyme
Hydromethylthionine mesylateMicrotubule-associated protein tautarget
MesoridazineD(2) dopamine receptortarget
Mesoridazine5-hydroxytryptamine receptor 2Atarget
MesoridazineCytochrome P450 2D6enzyme
MethotrimeprazineAlpha-1D adrenergic receptortarget
MethotrimeprazineAlpha-1B adrenergic receptortarget
MethotrimeprazineAlpha-1A adrenergic receptortarget
MethotrimeprazineMuscarinic acetylcholine receptor M5target
MethotrimeprazineAlpha-2B adrenergic receptortarget
MethotrimeprazineMuscarinic acetylcholine receptor M3target
MethotrimeprazineMuscarinic acetylcholine receptor M2target
MethotrimeprazineMuscarinic acetylcholine receptor M1target
MethotrimeprazineHistamine H1 receptortarget
MethotrimeprazineD(3) dopamine receptortarget
MethotrimeprazineAlpha-2C adrenergic receptortarget
MethotrimeprazineCytochrome P450 2D6enzyme
MethotrimeprazineD(2) dopamine receptortarget
MethotrimeprazineD(1A) dopamine receptortarget
MethotrimeprazineD(1B) dopamine receptortarget
MethotrimeprazineD(4) dopamine receptortarget
MethotrimeprazineCytochrome P450 2E1enzyme
Methotrimeprazine5-hydroxytryptamine receptor 2Ctarget
Methotrimeprazine5-hydroxytryptamine receptor 2Atarget
MethotrimeprazineAlpha-2A adrenergic receptortarget
MethotrimeprazineMuscarinic acetylcholine receptor M4target
Methylene blueCytochrome P450 2C19enzyme
Methylene blueCytochrome P450 2C9enzyme
Methylene blueCytochrome P450 2C8enzyme
Methylene blueCytochrome P450 2B6enzyme
Methylene blueCytochrome P450 1A2enzyme
Methylene blueUDP-glucuronosyltransferase 1A9enzyme
Methylene blueUDP-glucuronosyltransferase 1A4enzyme
Methylene blueNitric oxide synthase 1target
Methylene blueGuanylate cyclase soluble subunit alpha-2target
Methylene blueCytochrome P450 3A4enzyme
Methylene blueAmine oxidase [flavin-containing] Atarget
Methylene blueCytochrome P450 2D6enzyme
Methylene blueFlavin reductase (NADPH)enzyme
Methylene blueMultidrug and toxin extrusion protein 1transporter
Methylene blueMultidrug and toxin extrusion protein 2transporter
Methylene blueSolute carrier family 22 member 2transporter
Methylene blueATP-dependent translocase ABCB1transporter
Methylene blueAlbumincarrier
Methylene blueCytochrome P450 3A5enzyme
MoricizineVoltage-gated sodium channel alpha subunittarget
MoricizineSodium channel protein type 5 subunit alphatarget
PerazineD(2) dopamine receptortarget
PericiazineAlpha-1B adrenergic receptortarget
PericiazineAlpha-2A adrenergic receptortarget
PericiazineD(1A) dopamine receptortarget
PericiazineAndrogen receptortarget
PerphenazineD(2) dopamine receptortarget
PerphenazineD(1A) dopamine receptortarget
PerphenazineCytochrome P450 2D6enzyme
PerphenazineCytochrome P450 1A2enzyme
PerphenazineCytochrome P450 2C18enzyme
PerphenazineCytochrome P450 2C19enzyme
PerphenazineCytochrome P450 2C8enzyme
PerphenazineCytochrome P450 2C9enzyme
PerphenazineCytochrome P450 3A4enzyme
PerphenazineAlbumincarrier
PerphenazineCalmodulintarget
PipotiazineCytochrome P450 2D6enzyme
PipotiazineCytochrome P450 3A4enzyme
PipotiazineD(2) dopamine receptortarget
PipotiazineD(1A) dopamine receptortarget
Pipotiazine5-hydroxytryptamine receptor 2Atarget
Pipotiazine5-hydroxytryptamine receptor 1Atarget
PipotiazineSolute carrier family 22 member 1transporter
PipotiazineAlbumincarrier
PipotiazineCytochrome P450 2C19enzyme
ProchlorperazineD(2) dopamine receptortarget
ProchlorperazineCytochrome P450 2D6enzyme
ProchlorperazineHistamine H1 receptortarget
ProchlorperazineAlpha-1 adrenergic receptorstarget
ProchlorperazineAlpha-2 adrenergic receptorstarget
PromazineHistamine H1 receptortarget
PromazineCytochrome P450 2C19enzyme
PromazineCytochrome P450 1A2enzyme
PromazineCytochrome P450 3A4enzyme
PromazineCytochrome P450 2C9enzyme
PromazineCytochrome P450 2D6enzyme
PromazineMuscarinic acetylcholine receptor M5target
PromazineMuscarinic acetylcholine receptor M1target
PromazineD(2) dopamine receptortarget
Promazine5-hydroxytryptamine receptor 2Atarget
PromazineAlpha-1A adrenergic receptortarget
Promazine5-hydroxytryptamine receptor 2Ctarget
PromethazineMuscarinic acetylcholine receptor M4target
PromethazineNMDA receptortarget
PromethazineD(2) dopamine receptortarget
PromethazineHistamine H1 receptortarget
PromethazineCalmodulintarget
PromethazineAlbumincarrier
PromethazineATP-binding cassette sub-family C member 4transporter
PromethazineATP-binding cassette sub-family C member 3transporter
PromethazineVoltage-gated Potassium Channelstarget
PromethazineVoltage-gated sodium channel alpha subunittarget
PromethazineP2 Purinoceptorstarget
PromethazineAlpha adrenergic receptortarget
PromethazineHistamine H2 receptortarget
PromethazineCytochrome P450 2C9enzyme
PromethazineATP-dependent translocase ABCB1transporter
PromethazineCytochrome P450 2B6enzyme
PromethazineCytochrome P450 2D6enzyme
PromethazineMuscarinic acetylcholine receptor M3target
PromethazineMuscarinic acetylcholine receptor M2target
PromethazineMuscarinic acetylcholine receptor M5target
PromethazineMuscarinic acetylcholine receptor M1target
ThiethylperazineD(2) dopamine receptortarget
ThioproperazineAlbumincarrier
ThioproperazineAlpha-1B adrenergic receptortarget
ThioproperazineAlpha-1A adrenergic receptortarget
ThioproperazineD(1A) dopamine receptortarget
ThioproperazineD(2) dopamine receptortarget
ThioridazineD(2) dopamine receptortarget
ThioridazineAlpha-1A adrenergic receptortarget
Thioridazine5-hydroxytryptamine receptor 2Atarget
ThioridazineD(1A) dopamine receptortarget
ThioridazineCytochrome P450 2C19enzyme
ThioridazineCytochrome P450 2D6enzyme
ThioridazineAlpha-1B adrenergic receptortarget
ThioridazineVoltage-gated inwardly rectifying potassium channel KCNH2target
ThioridazineCytochrome P450 2E1enzyme
Thioridazine5-hydroxytryptamine receptor 2Ctarget
TrifluoperazineAlpha-1A adrenergic receptortarget
TrifluoperazineNeuron-specific vesicular protein calcyontarget
TrifluoperazineXanthine dehydrogenase/oxidaseenzyme
TrifluoperazineUDP-glucuronosyltransferase 1A4enzyme
TrifluoperazineCytochrome P450 1A2enzyme
TrifluoperazineATP-dependent translocase ABCB1transporter
TrifluoperazineD(2) dopamine receptortarget
TrifluoperazineTroponin C, slow skeletal and cardiac musclestarget
TrifluoperazineProtein S100-A4target
TrifluoperazineCalmodulin-2target
TrifluoperazineCalmodulin-3target
TrifluoperazineCalmodulintarget
TrifluoperazineCalmodulin-1target
Trifluoperazine5-hydroxytryptamine receptor 2Atarget
Trifluoperazine5-hydroxytryptamine receptor 2Ctarget
TriflupromazineCholinesteraseenzyme
Triflupromazine5-hydroxytryptamine receptor 2Btarget
TriflupromazineMuscarinic acetylcholine receptor M2target
TriflupromazineMuscarinic acetylcholine receptor M1target
TriflupromazineD(2) dopamine receptortarget
TriflupromazineD(1A) dopamine receptortarget
TriflupromazineATP-dependent translocase ABCB1transporter