Aceprometazine

DB01615ExperimentalSmall molecule

Aceprometazine is a is a drug with neuroleptic and anti-histamine properties. Although not widely prescribed, it is used in combination with meprobamate for the treatment of sleep disorders in France...

Mechanism: Aceprometazine, acting as an H1-receptor antagonist can induce sedation by being able to cross the blood-brain-barrier and binding to H1-receptors in the central nervous system.
Curator reviewed
Primary indication: Aceprometazine is often used in combination with meprobamate for the treatment of sleep disorders.Curator reviewed
Formula / weight: C₁₉H₂₂N₂OS · 326.456 g/mol (avg)
Also known as: Acepromethazine

Resolves to

Compound

UNII984N9YTM4YCAS13461-01-3ChEMBLCHEMBL2104054ChEBI53770PubChem26035

Clinical / RWD

RxNorm161203PharmGKBPA164743727

Structure

InChIKeyXLOQNFNTQIRSOX-UHFFFAOYSA-NSMILESCC(CN1C2=CC=CC=C2SC2=C1C=C(C=C2)C(C)=O)N(C)C

Targets

P35367HRH1

What you can answer from here — as of September 13, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1,105Drug interactionsStructured to mechanism, not free text

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Aceprometazine, and which of those have an active Phase 3 trial?

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