Histamine H1 receptor

BE0000442ProteinHumansHRH1

G protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:33828102, PubMed:8280179). It is acted on by 148 drugs in DrugBank.

Gene name
HRH1
UniProtKB entry
P35367Swiss-Prot
Cellular location
Cell membrane
Residues / weight
487 residues · 55,784 Da
Also known as
H1-R · H1R · HH1R

Resolves to

Protein
UniProtP35367UniProt nameHRH1_HUMAN
Gene
HGNCHGNC:5182NCBI Gene3269GenBank510296GeneCardsHRH1
Pharmacology
IUPHAR/GtoPdb262KEGGhsa:3269
Structure
PDB3RZEPDB7DFLPDB8X5X
Drugs

What you can answer from here — as of September 07, 2019

148DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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686+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Histamine H1 receptor, how selective are they, and which programs against it are still in active trials?

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