Identification
- Generic Name
- 2,2':6',2''-Terpyridine Platinum(Ii)
- DrugBank Accession Number
- DB01912
- Background
2,2':6',2''-terpyridine Platinum(Ii) is a solid. Known drug targets of 2,2':6',2''-Terpyridine Platinum(Ii) include truncated transposase and autolysin.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for 2,2':6',2''-Terpyridine Platinum(Ii) (DB01912)
- Weight
- Average: 463.805
Monoisotopic: 463.028924523 - Chemical Formula
- C15H11ClN3Pt
- Synonyms
- Not Available
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UAutolysin Not Available Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) UTruncated transposase Not Available Escherichia coli - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Not Available
- CAS number
- Not Available
- InChI Key
- XTQMQLRZXBEQCS-UHFFFAOYSA-M
- InChI
- InChI=1S/C15H11N3.ClH.Pt/c1-3-10-16-12(6-1)14-8-5-9-15(18-14)13-7-2-4-11-17-13;;/h1-11H;1H;/q;;+2/p-1
- IUPAC Name
- platinum(2+) 6-(pyridin-2-yl)-2,2'-bipyridine chloride
- SMILES
- [Cl-].[Pt++].C1=CC=C(N=C1)C1=CC=CC(=N1)C1=CC=CC=N1
References
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.129 mg/mL ALOGPS logP 2.78 ALOGPS logP 3.16 Chemaxon logS -3.3 ALOGPS pKa (Strongest Basic) 3.26 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 38.67 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 68.37 m3·mol-1 Chemaxon Polarizability 25.56 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9924 Blood Brain Barrier + 0.9738 Caco-2 permeable + 0.5221 P-glycoprotein substrate Substrate 0.5219 P-glycoprotein inhibitor I Non-inhibitor 0.732 P-glycoprotein inhibitor II Non-inhibitor 0.9031 Renal organic cation transporter Inhibitor 0.6951 CYP450 2C9 substrate Non-substrate 0.8612 CYP450 2D6 substrate Non-substrate 0.6332 CYP450 3A4 substrate Non-substrate 0.6513 CYP450 1A2 substrate Non-inhibitor 0.6556 CYP450 2C9 inhibitor Non-inhibitor 0.897 CYP450 2D6 inhibitor Non-inhibitor 0.8627 CYP450 2C19 inhibitor Non-inhibitor 0.8356 CYP450 3A4 inhibitor Non-inhibitor 0.9592 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.7069 Ames test Non AMES toxic 0.5 Carcinogenicity Non-carcinogens 0.9437 Biodegradation Not ready biodegradable 1.0 Rat acute toxicity 2.3812 LD50, mol/kg Not applicable hERG inhibition (predictor I) Strong inhibitor 0.6917 hERG inhibition (predictor II) Non-inhibitor 0.8198
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Targets
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- Kind
- Protein
- Organism
- Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
- Pharmacological action
- Unknown
- General Function
- N-acetylmuramoyl-l-alanine amidase activity
- Specific Function
- Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Autolys...
- Gene Name
- lytA
- Uniprot ID
- P06653
- Uniprot Name
- Autolysin
- Molecular Weight
- 36544.235 Da
References
- Kind
- Protein
- Organism
- Escherichia coli
- Pharmacological action
- Unknown
- General Function
- Transposase activity
- Specific Function
- Not Available
- Gene Name
- tnp
- Uniprot ID
- Q46730
- Uniprot Name
- Transposase
- Molecular Weight
- 50490.335 Da
Drug created at June 13, 2005 13:24 / Updated at June 12, 2020 16:52