Methylthioinosine

Identification

Generic Name
Methylthioinosine
DrugBank Accession Number
DB02896
Background

An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position.

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 298.318
Monoisotopic: 298.073575646
Chemical Formula
C11H14N4O4S
Synonyms
  • 6-(Methylthio)purine ribonucleoside
  • 6-methyl MP riboside
  • 6-methyl MP-riboside
  • 6-methyl-9-ribofuranosylpurine-6-thiol
  • 6-methylmercaptopurine ribonucleoside
  • 6-methylmercaptopurine riboside
  • 6-Methylmercaptopurine-riboside
  • 6-methylthioinosine
  • 6-methylthiopurine riboside
  • 6-MMPR
  • 6-S-methyl-6-thioinosine
  • Me6MPR
  • methylmercaptopurine riboside
  • MMPR
External IDs
  • NCI-C04784
  • NSC-40774
  • NSC-49555
  • SQ-21977

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UPurine nucleoside phosphorylase DeoD-typeNot AvailableEscherichia coli (strain K12)
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

IPR-RAT LD50: 65 mg/kg

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as purine nucleosides. These are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety.
Kingdom
Organic compounds
Super Class
Nucleosides, nucleotides, and analogues
Class
Purine nucleosides
Sub Class
Not Available
Direct Parent
Purine nucleosides
Alternative Parents
Glycosylamines / 6-thiopurines / Pentoses / Alkylarylthioethers / Pyrimidines and pyrimidine derivatives / N-substituted imidazoles / Tetrahydrofurans / Heteroaromatic compounds / Secondary alcohols / Sulfenyl compounds
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Substituents
6-thiopurine / Alcohol / Alkylarylthioether / Aromatic heteropolycyclic compound / Aryl thioether / Azacycle / Azole / Glycosyl compound / Heteroaromatic compound / Hydrocarbon derivative
show 22 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
thiopurine, purine ribonucleoside (CHEBI:44081)
Affected organisms
Not Available

Chemical Identifiers

UNII
Y5G39SHR0V
CAS number
342-69-8
InChI Key
ZDRFDHHANOYUTE-IOSLPCCCSA-N
InChI
InChI=1S/C11H14N4O4S/c1-20-10-6-9(12-3-13-10)15(4-14-6)11-8(18)7(17)5(2-16)19-11/h3-5,7-8,11,16-18H,2H2,1H3/t5-,7-,8-,11-/m1/s1
IUPAC Name
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(methylsulfanyl)-9H-purin-9-yl]oxolane-3,4-diol
SMILES
CSC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

References

General References
Not Available
PubChem Compound
9570
PubChem Substance
46505005
ChemSpider
9195
BindingDB
50412071
ChEBI
44081
ChEMBL
CHEMBL388931
ZINC
ZINC000000519128
PDBe Ligand
MTP
PDB Entries
1pr4 / 2aa0 / 2ab8 / 6c9p
MSDS
Download (51.5 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)164 °CPhysProp
logP0.09SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility8.21 mg/mLALOGPS
logP-0.4ALOGPS
logP-0.63ChemAxon
logS-1.6ALOGPS
pKa (Strongest Acidic)12.45ChemAxon
pKa (Strongest Basic)4.5ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area113.52 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity71.25 m3·mol-1ChemAxon
Polarizability28.81 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption-0.5
Blood Brain Barrier-0.6699
Caco-2 permeable-0.7396
P-glycoprotein substrateNon-substrate0.7196
P-glycoprotein inhibitor INon-inhibitor0.9212
P-glycoprotein inhibitor IINon-inhibitor0.9449
Renal organic cation transporterNon-inhibitor0.9198
CYP450 2C9 substrateNon-substrate0.7261
CYP450 2D6 substrateNon-substrate0.8166
CYP450 3A4 substrateNon-substrate0.5213
CYP450 1A2 substrateNon-inhibitor0.9183
CYP450 2C9 inhibitorNon-inhibitor0.9273
CYP450 2D6 inhibitorNon-inhibitor0.9508
CYP450 2C19 inhibitorNon-inhibitor0.9252
CYP450 3A4 inhibitorNon-inhibitor0.9866
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9057
Ames testAMES toxic0.8296
CarcinogenicityNon-carcinogens0.8857
BiodegradationNot ready biodegradable0.8971
Rat acute toxicity2.4718 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9949
hERG inhibition (predictor II)Non-inhibitor0.8175
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Targets

Drugtargets
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Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
General Function
Purine-nucleoside phosphorylase activity
Specific Function
Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules.
Gene Name
deoD
Uniprot ID
P0ABP8
Uniprot Name
Purine nucleoside phosphorylase DeoD-type
Molecular Weight
25949.68 Da
References
  1. Bennett EM, Li C, Allan PW, Parker WB, Ealick SE: Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase. J Biol Chem. 2003 Nov 21;278(47):47110-8. Epub 2003 Aug 21. [Article]

Drug created on June 13, 2005 13:24 / Updated on January 07, 2021 03:10