Purine nucleoside phosphorylase DeoD-type

BE0002011ProteinEscherichia coli (strain K12)deoD

Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:11786017, PubMed:21672603, PubMed:235429, PubMed:30337572). It is acted on by 13 drugs in DrugBank.

Gene name
deoD
UniProtKB entry
P0ABP8Swiss-Prot
Residues / weight
239 residues · 25,950 Da
Also known as
2.4.2.1 · Inosine phosphorylase · PNP · pup

Resolves to

Protein
UniProtP0ABP8UniProt nameDEOD_ECOLI
Gene
NCBI Gene945654GenBank147309
Pharmacology
KEGGecj:JW4347
Structure
PDB1A69PDB1ECPPDB1K9S
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Purine nucleoside phosphorylase DeoD-type, how selective are they, and which programs against it are still in active trials?

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