Drug Interactions: This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions: No interactions found.

Products

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Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Methylcobalamin	Injection	1 mg/1mL	Intramuscular	Perdido Key Health And Wellness Inc	2015-11-20	Not applicable

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
B12 1000mcg (methylcobalamin)	Tablet	1000 mcg	Oral	Natural Factors Nutritional Products Ltd.	2004-01-20	2009-09-28
CITREX MECOLAMIN 500MCG TABLET	Tablet, film coated		Oral	IDAMAN PHARMA MANUFACTURING SDN BHD	2020-09-08	Not applicable
Cobalmin 0.5mg Film-Coated Tablet	Tablet, film coated		Oral	Advance Pharma Sdn Bhd	2020-09-08	Not applicable
Live-well™ MECOMIN Capsule	Capsule		Oral	PAHANG PHARMACY SDN. BHD.	2020-09-08	Not applicable
MEBAAL-500	Tablet, film coated	0.5 mg	Oral	บริษัท เมก้า ไลฟ์ไซแอ็นซ์ จำกัด (มหาชน)	2016-08-15	Not applicable
Mecobal Tablet 500mcg	Tablet, film coated		Oral	IDAMAN PHARMA SDN. BHD.	2020-09-08	Not applicable
Mecobamin Coated Tablet 500 mcg	Tablet, coated		Oral	NOVA LABORATORIES SDN. BHD.	2020-09-08	Not applicable
MECOVIT 500 MCG CAPSULE	Capsule		Oral	Noripharma Sdn. Bhd.	2020-09-08	Not applicable
MECOVIT 500 MCG TABLET	Tablet		Oral	Noripharma Sdn. Bhd.	2020-09-08	Not applicable
MERABIN	Capsule	0.5 mg	Oral	บริษัท ฟาร์มาแลนด์ (1982) จำกัด	2005-05-25	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
B-cobal Film-coated tab	Mecobalamin (0.1 mg) + Pyridoxine (200 mg) + Thiamine (100 mg)	Tablet, film coated	Oral	AV MANUFACTURING SDN.BHD	2020-09-08	Not applicable
BEGOLIN PLUS 150MG/1MG FILM TABLET ,56 FILM TABLET	Mecobalamin (1 mg) + Pregabalin (150 mg)	Tablet, film coated	Oral	ABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş.	2020-08-14	Not applicable
BEGOLIN PLUS 300MG/1MG FILM TABLET ,56 TABLET	Mecobalamin (1 mg) + Pregabalin (300 mg)	Tablet, film coated	Oral	ABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş.	2020-08-14	Not applicable
BEGOLIN PLUS 75MG/1MG FILM TABLET ,TABLET, 14 ADET	Mecobalamin (1 mg) + Pregabalin (75 mg)	Tablet, film coated	Oral	ABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş.	2020-08-14	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
B-Combo	Mecobalamin (1 mg/1mL) + Dexpanthenol (1 mg/1mL) + Nicotinamide (1 mg/1mL) + Pyridoxine (1 mg/1mL) + Riboflavin (1 mg/1mL) + Thiamine chloride (1 mg/1mL)	Injection	Intramuscular	Perdido Key Health And Wellness Inc	2015-11-23	Not applicable
Co-Balamin	Mecobalamin (5 mg/1mg) + Folic acid (0.8 mg/1mg) + Resveratrol (400 mg/1mg) + Ubiquinol (200 mg/1mg)	Capsule	Oral	Home Aide Diagnostics, Inc.	2015-08-01	Not applicable
Co-Veratrol	Mecobalamin (5 mg/1mg) + Folic acid (0.8 mg/1mg) + Resveratrol (400 mg/1mg) + Ubiquinol (200 mg/1mg)	Capsule	Oral	Home Aide Diagnostics, Inc.	2015-08-01	2018-10-05
Dyzbac	Mecobalamin (1 mg/1) + Ascorbic acid (150 mg/1) + Cholecalciferol (0.0125 mg/1) + Leucovorin (1 mg/1) + Lipoic acid (125 mg/1) + Pyridoxal phosphate (12.5 mg/1) + Resveratrol (50 mg/1) + Ubidecarenone (50 mg/1)	Tablet	Oral	Basiem	2015-10-28	2015-11-01
Dyzbac	Mecobalamin (1 mg/1) + Ascorbic acid (125 mg/1) + Cholecalciferol (500 [iU]/1) + Leucovorin (1 mg/1) + Lipoic acid (150 mg/1) + Pyridoxal phosphate (12.5 mg/1) + Resveratrol (50 mg/1) + Ubidecarenone (25 mg/1)	Tablet	Oral	Basiem	2015-11-05	2016-01-01
EnLyte Extra-LN	Mecobalamin (25 ug/1) + Cobamamide (25 ug/1) + Dihydrofolic Acid (1 mg/1) + Gastric intrinsic factor (25 mg/1)	Capsule	Oral	Jaymac Pharmacueticals LLC	2019-12-16	Not applicable
Folinex	Mecobalamin (1 mg/1) + Ascorbic acid (355 mg/1) + Folic acid (1 mg/1) + Vitamin K7 (100 ug/1)	Capsule	Oral	Vivera Pharmaceuticals, Inc.	2020-02-07	Not applicable
healthy mamaBE WELL ROUNDED BE WELL ROUNDED	Mecobalamin (8 ug/1) + Ascorbic acid (120 mg/1) + Beta carotene (4000 [iU]/1) + Biotin (30 ug/1) + Calcium carbonate (200 mg/1) + Cholecalciferol (400 [iU]/1) + Copper (2 mg/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Ferrous bisglycinate (28 mg/1) + Folic acid (800 ug/1) + Magnesium oxide (30 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (2.6 mg/1) + Riboflavin (1.7 mg/1) + Thiamine chloride (1.8 mg/1) + Zinc oxide (25 mg/1)	Tablet, film coated	Oral	MATERNAL SCIENCE, LLC	2013-07-09	Not applicable
L-Methyl MC NAC	Mecobalamin (2 mg/1) + Acetylcysteine (600 mg/1) + Levomefolate calcium (6 mg/1)	Tablet, coated	Oral	Virtus Pharmaceuticals	2014-04-09	2015-02-15
L-Methyl-B6-B12	Mecobalamin (2 mg/1) + Levomefolate calcium (15 mg/1) + Pyridoxal phosphate (35 mg/1)	Tablet, coated	Oral	Virtus Pharmaceuticals	2012-03-15	2012-08-03

Chemical Identifiers

UNII: BR1SN1JS2W
CAS number: 13422-55-4
InChI Key: JEWJRMKHSMTXPP-WZHZPDAFSA-L
InChI: InChI=1S/C62H90N13O14P.CH3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H3;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;/m1../s1
IUPAC Name: (10S,12R,13S,17R,23R,24R,25R,30S,35S,36S,40S,41S,42R,46R)-30,35,40-tris(2-carbamoylethyl)-24,36,41-tris(carbamoylmethyl)-46-hydroxy-12-(hydroxymethyl)-1,5,6,17,23,28,31,31,36,38,41,42-dodecamethyl-15,20-dioxo-11,14,16-trioxa-2lambda5,9,19,26,43lambda5,44lambda5,45lambda5-heptaaza-15lambda5-phospha-1-cobaltadodecacyclo[27.14.1.1^{1,34}.1^{2,9}.1^{10,13}.0^{1,26}.0^{3,8}.0^{23,27}.0^{25,42}.0^{32,44}.0^{39,43}.0^{37,45}]heptatetraconta-2(47),3,5,7,27,29(44),32,34(45),37,39(43)-decaene-2,43,44,45-tetrakis(ylium)-1,1,1-triuid-15-olate
SMILES: C1(CC[C@@]2([C@@H](CC(N)=O)[C@@]3([C@@]4([N+]5=C([C@H]([C@@]4(CC(N)=O)C)CCC(N)=O)C(C)=C4[N+]6=C(C=C7[N+]8=C([C@H](C7(C)C)CCC(N)=O)C(C)=C2N3[Co-3]568([N+]2=CN([C@H]3O[C@@H]([C@@H](OP(O[C@@H](CN1)C)([O-])=O)[C@H]3O)CO)C1=CC(C)=C(C=C21)C)C)[C@H]([C@@]4(CC(N)=O)C)CCC(N)=O)C)[H])C)=O

References

General References

Not Available

External Links

Human Metabolome Database: HMDB0002274
KEGG Drug: D03246
KEGG Compound: C06453
PubChem Compound: 71306319
PubChem Substance: 46506610
ChemSpider: 28534328
RxNav: 29421
ChEBI: 28115
ChEMBL: CHEMBL2448537
PDBe Ligand: COB
Wikipedia: Methylcobalamin

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Completed	Prevention	Vincristine Induced Peripheral Neuropathy (VIPN)	1
4	Completed	Treatment	Dementia With Vitamin B12 Deficiency	1
4	Completed	Treatment	Peripheral neuropathy	1
3	Unknown Status	Treatment	Amyotrophic Lateral Sclerosis (ALS)	1
2	Completed	Treatment	Vitamin B12 Deficiency	1
2	Recruiting	Treatment	Diabetic Neuropathies	1
2, 3	Completed	Prevention	Acute Lymphoblastic Leukemia (ALL) / Vincristine Induced Neurotoxicity	1
2, 3	Completed	Treatment	Amyotrophic Lateral Sclerosis (ALS)	2
2, 3	Completed	Treatment	Autistic Disorder	2
2, 3	Completed	Treatment	Pulmonary Functions / Type 2 Diabetes Mellitus	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Bar, chewable	Oral
Tablet	Oral	1000 mcg
Injection	Intramuscular
Tablet, film coated	Oral
Tablet	Oral
Tablet, coated	Oral
Injection	Intramuscular
Capsule	Oral
Tablet, film coated	Oral
Tablet, coated	Oral
Capsule	Oral	0.5 mg
Capsule	Oral
Tablet, sugar coated	Oral
Solution		0.5 mg/1ml
Injection, solution		0.5 mg
Solution		0.5 mg
Injection	Intramuscular	1 mg/1mL
Powder	Not applicable	1 g/1g
Tablet	Oral
Capsule, liquid filled	Oral
Kit	Oral
Tablet, chewable	Oral
Capsule, gelatin coated	Oral
Tablet	Oral	0.5 mg
Tablet, film coated	Oral	0.5 mg
Tablet, sugar coated	Oral	0.5 mg

Prices

Not Available

Patents

Not Available

Properties

State

Solid

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
logP	-14	ChemAxon
pKa (Strongest Acidic)	1.82	ChemAxon
pKa (Strongest Basic)	-0.44	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	13	ChemAxon
Hydrogen Donor Count	9	ChemAxon
Polar Surface Area	417 Å²	ChemAxon
Rotatable Bond Count	16	ChemAxon
Refractivity	342.79 m³·mol^-1	ChemAxon
Polarizability	135.93 Å³	ChemAxon
Number of Rings	12	ChemAxon
Bioavailability	0	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Predicted ADMET Features

Property	Value	Probability
Human Intestinal Absorption	-	0.6014
Blood Brain Barrier	-	0.8526
Caco-2 permeable	-	0.6453
P-glycoprotein substrate	Substrate	0.8965
P-glycoprotein inhibitor I	Inhibitor	0.5153
P-glycoprotein inhibitor II	Inhibitor	0.6647
Renal organic cation transporter	Non-inhibitor	0.8463
CYP450 2C9 substrate	Non-substrate	0.8011
CYP450 2D6 substrate	Non-substrate	0.8117
CYP450 3A4 substrate	Substrate	0.7142
CYP450 1A2 substrate	Non-inhibitor	0.8313
CYP450 2C9 inhibitor	Non-inhibitor	0.8338
CYP450 2D6 inhibitor	Non-inhibitor	0.8608
CYP450 2C19 inhibitor	Non-inhibitor	0.7142
CYP450 3A4 inhibitor	Inhibitor	0.6587
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.8552
Ames test	Non AMES toxic	0.5744
Carcinogenicity	Non-carcinogens	0.815
Biodegradation	Not ready biodegradable	0.9827
Rat acute toxicity	2.6923 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.8771
hERG inhibition (predictor II)	Non-inhibitor	0.5706

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST): Not Available
Spectra: Not Available

Targets

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Details1. Methionine synthase

Kind: Protein
Organism: Humans
Pharmacological action: Yes
Actions: Cofactor

General Function: Zinc ion binding
Specific Function: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofola...
Gene Name: MTR
Uniprot ID: Q99707
Uniprot Name: Methionine synthase
Molecular Weight: 140525.91 Da

References

Zhang YF, Ning G: Mecobalamin. Expert Opin Investig Drugs. 2008 Jun;17(6):953-64. doi: 10.1517/13543784.17.6.953. [Article]

Drug created on June 13, 2005 13:24 / Updated on February 21, 2021 18:51

Mecobalamin

Identification

Structure for Mecobalamin (DB03614)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra

Targets

References