Mecobalamin
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Identification
- Generic Name
- Mecobalamin
- DrugBank Accession Number
- DB03614
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
- Weight
- Average: 1344.3823
Monoisotopic: 1343.587806391 - Chemical Formula
- C63H91CoN13O14P
- Synonyms
- Co-methylcobalamin
- MeCbl
- Mecobalamin
- Mecobalamina
- Mecobalaminum
- Methyl vitamin B12
- Methyl(III)cobalamin
- Methylcobalamin
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
- Associated Therapies
- Contraindications & Blackbox Warnings
- Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.
- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism AMethionine synthase cofactorHumans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Methylcobalamin Injection 1 mg/1mL Intramuscular Perdido Key Health And Wellness Inc 2015-11-20 Not applicable US - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image B12 1000mcg (methylcobalamin) Tablet 1000 mcg Oral Natural Factors Nutritional Products Ltd. 2004-01-20 2009-09-28 Canada CITREX MECOLAMIN 500MCG TABLET Tablet, film coated Oral IDAMAN PHARMA MANUFACTURING SDN BHD 2020-09-08 Not applicable Malaysia Cobalmin 0.5mg Film-Coated Tablet Tablet, film coated Oral Advance Pharma Sdn Bhd 2020-09-08 Not applicable Malaysia Live-well™ MECOMIN Capsule Capsule Oral PAHANG PHARMACY SDN. BHD. 2020-09-08 Not applicable Malaysia MEBAAL-500 Tablet, film coated 0.5 mg Oral บริษัท เมก้า ไลฟ์ไซแอ็นซ์ จำกัด (มหาชน) 2016-08-15 Not applicable Thailand Mecobal Tablet 500mcg Tablet, film coated 500 mcg Oral IDAMAN PHARMA SDN. BHD. 2020-09-08 Not applicable Malaysia Mecobamin Coated Tablet 500 mcg Tablet, coated Oral NOVA LABORATORIES SDN. BHD. 2020-09-08 Not applicable Malaysia MECOVIT 500 MCG CAPSULE Capsule Oral Noripharma Sdn. Bhd. 2020-09-08 Not applicable Malaysia MECOVIT 500 MCG TABLET Tablet Oral Noripharma Sdn. Bhd. 2020-09-08 Not applicable Malaysia MERABIN Capsule 0.5 mg Oral บริษัท ฟาร์มาแลนด์ (1982) จำกัด 2005-05-25 Not applicable Thailand - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image B-cobal Film-coated tab Mecobalamin (0.1 mg) + Pyridoxine (200 mg) + Thiamine (100 mg) Tablet, film coated Oral AV MANUFACTURING SDN.BHD 2020-09-08 Not applicable Malaysia BEGOLIN PLUS 150MG/1MG FILM TABLET ,56 FILM TABLET Mecobalamin (1 mg) + Pregabalin (150 mg) Tablet, film coated Oral ABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey BEGOLIN PLUS 300MG/1MG FILM TABLET ,56 TABLET Mecobalamin (1 mg) + Pregabalin (300 mg) Tablet, film coated Oral ABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey BEGOLIN PLUS 75MG/1MG FILM TABLET ,TABLET, 14 ADET Mecobalamin (1 mg) + Pregabalin (75 mg) Tablet, film coated Oral ABDİ İBRAHİM İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Abavite Mecobalamin (0.5 mg/1) + Ascorbic acid (60 mg/1) + Cholecalciferol (0.025 mg/1) + DL-alpha tocopheryl acetate (13.5 mg/1) + Ferrous sulfate (30 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (25 mg/1) + Niacin (15 mg/1) + Calcium pantothenate (5 mg/1) + Potassium Iodide (0.25 mg/1) + Riboflavin (1.8 mg/1) + Thiamine mononitrate (1.6 mg/1) + Vitamin A palmitate (0.33 mg/1) + Zinc oxide (15 mg/1) Tablet Oral ABACOS HEALTH 2021-03-31 Not applicable US B-Combo Mecobalamin (1 mg/1mL) + Dexpanthenol (1 mg/1mL) + Nicotinamide (1 mg/1mL) + Pyridoxine (1 mg/1mL) + Riboflavin (1 mg/1mL) + Thiamine chloride (1 mg/1mL) Injection Intramuscular Perdido Key Health And Wellness Inc 2015-11-23 Not applicable US Co-Balamin Mecobalamin (5 mg/1mg) + Folic acid (0.8 mg/1mg) + Resveratrol (400 mg/1mg) + Ubiquinol (200 mg/1mg) Capsule Oral Home Aide Diagnostics, Inc. 2015-08-01 Not applicable US Co-Veratrol Mecobalamin (5 mg/1mg) + Folic acid (0.8 mg/1mg) + Resveratrol (400 mg/1mg) + Ubiquinol (200 mg/1mg) Capsule Oral Home Aide Diagnostics, Inc. 2015-08-01 2018-10-05 US Dyzbac Mecobalamin (1 mg/1) + Ascorbic acid (150 mg/1) + Cholecalciferol (0.0125 mg/1) + Leucovorin (1 mg/1) + Lipoic acid (125 mg/1) + Pyridoxal phosphate (12.5 mg/1) + Resveratrol (50 mg/1) + Ubidecarenone (50 mg/1) Tablet Oral Basiem 2015-10-28 2015-11-01 US Dyzbac Mecobalamin (1 mg/1) + Ascorbic acid (125 mg/1) + Cholecalciferol (500 [iU]/1) + Leucovorin (1 mg/1) + Lipoic acid (150 mg/1) + Pyridoxal phosphate (12.5 mg/1) + Resveratrol (50 mg/1) + Ubidecarenone (25 mg/1) Tablet Oral Basiem 2015-11-05 2016-01-01 US EnLyte Extra-LN Mecobalamin (25 ug/1) + Cobamamide (25 ug/1) + Dihydrofolic Acid (1 mg/1) + Gastric intrinsic factor (25 mg/1) Capsule Oral Jaymac Pharmacueticals LLC 2019-12-16 Not applicable US Folinex Mecobalamin (1 mg/1) + Ascorbic acid (355 mg/1) + Folic acid (1 mg/1) + Vitamin K7 (100 ug/1) Capsule Oral Vivera Pharmaceuticals, Inc. 2020-02-07 Not applicable US healthy mamaBE WELL ROUNDED BE WELL ROUNDED Mecobalamin (8 ug/1) + Ascorbic acid (120 mg/1) + Beta carotene (4000 [iU]/1) + Biotin (30 ug/1) + Calcium carbonate (200 mg/1) + Cholecalciferol (400 [iU]/1) + Copper (2 mg/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Ferrous bisglycinate (28 mg/1) + Folic acid (800 ug/1) + Magnesium oxide (30 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (2.6 mg/1) + Riboflavin (1.7 mg/1) + Thiamine chloride (1.8 mg/1) + Zinc oxide (25 mg/1) Tablet, film coated Oral MATERNAL SCIENCE, LLC 2013-07-09 Not applicable US L-Methyl MC NAC Mecobalamin (2 mg/1) + Acetylcysteine (600 mg/1) + Levomefolate calcium (6 mg/1) Tablet, coated Oral Virtus Pharmaceuticals 2014-04-09 2015-02-15 US
Categories
- ATC Codes
- B03BA05 — Mecobalamin
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as cobalamin derivatives. These are organic compounds containing a corrin ring, a cobalt atom, an a nucleotide moiety. Cobalamin Derivatives are actually derived from vitamin B12.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Tetrapyrroles and derivatives
- Sub Class
- Corrinoids
- Direct Parent
- Cobalamin derivatives
- Alternative Parents
- Metallotetrapyrroles / Pentose phosphates / Monosaccharide phosphates / Benzimidazoles / Benzenoids / Fatty amides / N-substituted imidazoles / Organic phosphoric acids and derivatives / Tetrahydrofurans / Pyrrolines show 19 more
- Substituents
- Alcohol / Aromatic heteropolycyclic compound / Azacycle / Azole / Benzenoid / Benzimidazole / Carbonyl group / Carboxamide group / Carboxylic acid derivative / Cobalamin show 35 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- cobalamins (CHEBI:28115)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- BR1SN1JS2W
- CAS number
- 13422-55-4
- InChI Key
- JEWJRMKHSMTXPP-WZHZPDAFSA-L
- InChI
- InChI=1S/C62H90N13O14P.CH3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H3;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;/m1../s1
- IUPAC Name
- (10S,12R,13S,17R,23R,24R,25R,30S,35S,36S,40S,41S,42R,46R)-30,35,40-tris(2-carbamoylethyl)-24,36,41-tris(carbamoylmethyl)-46-hydroxy-12-(hydroxymethyl)-1,5,6,17,23,28,31,31,36,38,41,42-dodecamethyl-15,20-dioxo-11,14,16-trioxa-2lambda5,9,19,26,43lambda5,44lambda5,45lambda5-heptaaza-15lambda5-phospha-1-cobaltadodecacyclo[27.14.1.1^{1,34}.1^{2,9}.1^{10,13}.0^{1,26}.0^{3,8}.0^{23,27}.0^{25,42}.0^{32,44}.0^{39,43}.0^{37,45}]heptatetraconta-2(47),3,5,7,27,29(44),32,34(45),37,39(43)-decaene-2,43,44,45-tetrakis(ylium)-1,1,1-triuid-15-olate
- SMILES
- C1(CC[C@@]2([C@@H](CC(N)=O)[C@@]3([C@@]4([N+]5=C([C@H]([C@@]4(CC(N)=O)C)CCC(N)=O)C(C)=C4[N+]6=C(C=C7[N+]8=C([C@H](C7(C)C)CCC(N)=O)C(C)=C2N3[Co-3]568([N+]2=CN([C@H]3O[C@@H]([C@@H](OP(O[C@@H](CN1)C)([O-])=O)[C@H]3O)CO)C1=CC(C)=C(C=C21)C)C)[C@H]([C@@]4(CC(N)=O)C)CCC(N)=O)C)[H])C)=O
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0002274
- KEGG Drug
- D03246
- KEGG Compound
- C06453
- PubChem Compound
- 71306319
- PubChem Substance
- 46506610
- ChemSpider
- 28534328
- 29421
- ChEBI
- 28115
- ChEMBL
- CHEMBL2448537
- PDBe Ligand
- COB
- Wikipedia
- Methylcobalamin
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Vincristine Induced Peripheral Neuropathy (VIPN) 1 4 Completed Treatment Dementia With Vitamin B12 Deficiency 1 4 Completed Treatment Peripheral neuropathy 1 4 Recruiting Treatment Diabetes 1 3 Not Yet Recruiting Prevention Palmar-Plantar Erythrodysesthesia 1 3 Unknown Status Treatment Amyotrophic Lateral Sclerosis (ALS) 1 2 Completed Treatment Vitamin B12 Deficiency 1 2 Unknown Status Treatment Diabetic Neuropathies 1 2 Unknown Status Treatment Injuries, Brain caused by Alcohol Use 1 2, 3 Completed Prevention Acute Lymphoblastic Leukaemias (ALL) / Vincristine Induced Neurotoxicity 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Bar, chewable Oral Tablet Oral 1000 mcg Injection Intramuscular Tablet, film coated Oral Capsule Oral 500 MCG Tablet, film coated Oral 500 Mcg Tablet Oral Tablet, coated Oral Injection Intramuscular Capsule Oral Tablet, coated Oral Capsule Oral 0.5 mg Capsule Oral Injection Intramuscular 500 MCG/ML Tablet, sugar coated Oral Injection Intramuscular 500 MCG Solution 0.5 mg/1ml Injection Intravenous 500 mcg/ml Tablet, sugar coated Oral 500 mcg Injection, solution 0.5 mg Solution 0.5 mg Injection Intramuscular 1 mg/1mL Powder Not applicable 1 g/1g Tablet, film coated Oral Tablet Oral Capsule, liquid filled Oral Kit Oral Tablet, chewable Oral Tablet Oral 500 mcg Capsule, gelatin coated Oral Tablet Oral 0.5 mg Tablet, film coated Oral 0.5 mg Tablet, sugar coated Oral 0.5 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP -14 Chemaxon pKa (Strongest Acidic) 1.82 Chemaxon pKa (Strongest Basic) -0.44 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 13 Chemaxon Hydrogen Donor Count 9 Chemaxon Polar Surface Area 417 Å2 Chemaxon Rotatable Bond Count 16 Chemaxon Refractivity 342.79 m3·mol-1 Chemaxon Polarizability 135.93 Å3 Chemaxon Number of Rings 12 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption - 0.6014 Blood Brain Barrier - 0.8526 Caco-2 permeable - 0.6453 P-glycoprotein substrate Substrate 0.8965 P-glycoprotein inhibitor I Inhibitor 0.5153 P-glycoprotein inhibitor II Inhibitor 0.6647 Renal organic cation transporter Non-inhibitor 0.8463 CYP450 2C9 substrate Non-substrate 0.8011 CYP450 2D6 substrate Non-substrate 0.8117 CYP450 3A4 substrate Substrate 0.7142 CYP450 1A2 substrate Non-inhibitor 0.8313 CYP450 2C9 inhibitor Non-inhibitor 0.8338 CYP450 2D6 inhibitor Non-inhibitor 0.8608 CYP450 2C19 inhibitor Non-inhibitor 0.7142 CYP450 3A4 inhibitor Inhibitor 0.6587 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8552 Ames test Non AMES toxic 0.5744 Carcinogenicity Non-carcinogens 0.815 Biodegradation Not ready biodegradable 0.9827 Rat acute toxicity 2.6923 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.8771 hERG inhibition (predictor II) Non-inhibitor 0.5706
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Targets

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1. DetailsMethionine synthase
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Cofactor
- General Function
- Zinc ion binding
- Specific Function
- Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofola...
- Gene Name
- MTR
- Uniprot ID
- Q99707
- Uniprot Name
- Methionine synthase
- Molecular Weight
- 140525.91 Da
References
- Zhang YF, Ning G: Mecobalamin. Expert Opin Investig Drugs. 2008 Jun;17(6):953-64. doi: 10.1517/13543784.17.6.953. [Article]
Drug created at June 13, 2005 13:24 / Updated at September 28, 2021 21:54