Methionine synthase

BE0000734ProteinHumansMTR

Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol (PubMed:16769880, PubMed:17288554, PubMed:27771510). It is acted on by 9 drugs in DrugBank.

Gene name
MTR
UniProtKB entry
Q99707Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,265 residues · 140,526 Da
Also known as
2.1.1.13 · 5-methyltetrahydrofolate--homocysteine methyltransferase · Cobalamin-dependent methionine synthase · MS · Vitamin-B12 dependent methionine synthase

Resolves to

Protein
UniProtQ99707UniProt nameMETH_HUMAN
Gene
HGNCHGNC:7468NCBI Gene4548GenBank1923221GeneCardsMTR
Pharmacology
KEGGhsa:4548
Structure
PDB2O2KPDB4CCZPDB9SSP
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Metabolic reactionDrug transformations it catalyses, substrate to product
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
5Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
34+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Methionine synthase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In