Identification

Summary

Didecyldimethylammonium is a disinfectant and microbicidal agent used in a variety of products.

Generic Name
Didecyldimethylammonium
DrugBank Accession Number
DB04221
Background

Not Available

Type
Small Molecule
Groups
Approved, Experimental
Structure
Weight
Average: 326.6232
Monoisotopic: 326.378675541
Chemical Formula
C22H48N
Synonyms
  • Didecyl-dimethyl-ammonium
  • Didecyldimethylammonium cation
  • Didecyldimethylammonium ion
  • Didecyldimonium

Pharmacology

Indication

Not Available

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Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UPhospholipid membraneNot AvailableEscherichia coli (strain K12)
UCyclopropane mycolic acid synthase 2Not AvailableMycobacterium tuberculosis
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Didecyldimethylammonium chlorideJXN40O9Y9B7173-51-5RUPBZQFQVRMKDG-UHFFFAOYSA-M
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Chloroqcare Antiseptic Hand CareLiquid117 mg/60mLTopicalWartkang Medical Technology Co., Ltd2021-11-10Not applicableUS flag
Hand Sanitizing WipesCloth0.15 1/1001TopicalShandong BaiHe Sanitary Products Co., Ltd.2020-11-23Not applicableUS flag
OKGO DisinfectantSpray0.5 mg/1mLTopicalHenan Seagood Medical Equipment Co., Ltd.2021-01-26Not applicableUS flag
S D SGel0.2 g/100mLTopicalXi'an Explution Tech Co.,Ltd.2020-04-29Not applicableUS flag
Steri Hand sanitizer without washingLiquid1 mg/500mLExtracorporealQingdao Kangweilong Disinfection Technology Co.,Ltd.2020-04-27Not applicableUS flag
Surface DisinfectantSpray0.2 g/100mLTopicalXi'an Explution Tech Co.,Ltd.2020-04-29Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
(Aenc) Disinfectant WATER-FREE HAND FOAMDidecyldimethylammonium chloride (0.11 mg/100mL) + Polihexanide (0.56 mg/100mL)SolutionTopicalYantai Dongke Lvzhiyuan Disinfection Pharmaceutical Co., Ltd.2020-05-202021-11-23US flag
Alcohol Wet TissueDidecyldimethylammonium chloride (0.1 g/100g) + Benzalkonium chloride (0.1 g/100g) + Cetylpyridinium chloride (0.05 g/100g) + Chlorphenesin (0.05 g/100g) + Ethanol (75 g/100g)SwabTopicalSHANDONG PROVINCE RUNHE SANITARY MATERIALS CO.,LTD.2020-04-13Not applicableUS flag
Alcohol Wet WipesDidecyldimethylammonium chloride (0.624 g/100g) + Benzalkonium chloride (0.624 g/100g) + Ethanol (30 g/100g)SwabTopicalSHANDONG PROVINCE RUNHE SANITARY MATERIALS CO.,LTD.2020-04-13Not applicableUS flag
Alcohol Wet WipesDidecyldimethylammonium chloride (0.624 g/100g) + Benzalkonium chloride (0.624 g/100g) + Ethanol (30 g/100g)SwabTopicalSHANDONG PROVINCE RUNHE SANITARY MATERIALS CO.,LTD.2020-04-13Not applicableUS flag
Alcohol WipesDidecyldimethylammonium chloride (0.188 g/501) + Benzalkonium chloride (0.188 g/501) + Ethanol (40 mL/501)ClothExtracorporealHangzhou Lin'an Sanxin Cleaning Products Co.,Ltd.2020-05-11Not applicableUS flag
Alcohol WipesDidecyldimethylammonium chloride (0.2 U/100U) + Benzalkonium chloride (0.15 U/100U) + Ethanol (15 U/100U)PatchTopicalFujian Yifa Healthcare Products Co., Ltd.2020-05-05Not applicableUS flag
Antibacterial Wet WipesDidecyldimethylammonium chloride (0.012 g/100g) + Benzalkonium chloride (0.156 g/100g) + Bronopol (0.061 g/100g) + Iodopropynyl butylcarbamate (0.077 g/100g)SwabTopicalSHANDONG PROVINCE RUNHE SANITARY MATERIALS CO.,LTD.2020-04-13Not applicableUS flag
Antibacterial Wet WipesDidecyldimethylammonium chloride (0.0567 g/101) + Benzalkonium chloride (0.042 g/101) + Ethanol (14.175 g/101)ClothTopicalHangzhou Linan Poem Clean Day Co., Ltd.2020-07-28Not applicableUS flag
Antibacterial Wet WipesDidecyldimethylammonium chloride (0.012 g/100g) + Benzalkonium chloride (0.156 g/100g) + Bronopol (0.061 g/100g) + Iodopropynyl butylcarbamate (0.077 g/100g)SwabTopicalSHANDONG PROVINCE RUNHE SANITARY MATERIALS CO.,LTD.2020-04-13Not applicableUS flag
Antibacterial WipesDidecyldimethylammonium chloride (0.2 g/1001) + Benzalkonium chloride (0.1 g/1001)ClothTopicalJiangyin Yinghuameng Houseware Co., Ltd.2020-03-30Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
(Aenc) Disinfectant WATER-FREE HAND FOAMDidecyldimethylammonium chloride (0.11 mg/100mL) + Polihexanide (0.56 mg/100mL)SolutionTopicalYantai Dongke Lvzhiyuan Disinfection Pharmaceutical Co., Ltd.2020-05-202021-11-23US flag
Alcohol Wet WipesDidecyldimethylammonium chloride (0.624 g/100g) + Benzalkonium chloride (0.624 g/100g) + Ethanol (30 g/100g)SwabTopicalSHANDONG PROVINCE RUNHE SANITARY MATERIALS CO.,LTD.2020-04-13Not applicableUS flag
Alcohol WipesDidecyldimethylammonium chloride (0.188 g/501) + Benzalkonium chloride (0.188 g/501) + Ethanol (40 mL/501)ClothExtracorporealHangzhou Lin'an Sanxin Cleaning Products Co.,Ltd.2020-05-11Not applicableUS flag
Antibacterial Wet WipesDidecyldimethylammonium chloride (0.012 g/100g) + Benzalkonium chloride (0.156 g/100g) + Bronopol (0.061 g/100g) + Iodopropynyl butylcarbamate (0.077 g/100g)SwabTopicalSHANDONG PROVINCE RUNHE SANITARY MATERIALS CO.,LTD.2020-04-13Not applicableUS flag
Chloroqcare Antiseptic Hand CareDidecyldimethylammonium chloride (117 mg/60mL)LiquidTopicalWartkang Medical Technology Co., Ltd2021-11-10Not applicableUS flag
Disinfectant Cleaning WipesDidecyldimethylammonium chloride (0.24 g/1601) + Benzalkonium chloride (0.12 g/1601) + Ethylhexylglycerin (0.12 g/1601) + Glycerin (0.12 g/1601) + Phenoxyethanol (0.6 g/1601) + Propylene glycol (0.12 g/1601)ClothExtracorporealReynard (Ningbo) Biotechnology Co., Ltd.2020-06-12Not applicableUS flag
Disinfectant WipesDidecyldimethylammonium chloride (0.188 g/501) + Benzalkonium chloride (0.188 g/501)ClothExtracorporealHangzhou Lin'an Sanxin Cleaning Products Co.,Ltd.2020-05-11Not applicableUS flag
Disinfecting WipesDidecyldimethylammonium chloride (0.24 g/1601) + Benzalkonium chloride (0.12 g/1601) + Ethylhexylglycerin (0.12 g/1601) + Glycerin (0.12 g/1601) + Phenoxyethanol (0.6 g/1601) + Propylene glycol (0.12 g/1601)ClothExtracorporealReynard (Ningbo) Biotechnology Co., Ltd.2020-04-17Not applicableUS flag
Hand Sanitizing WipesDidecyldimethylammonium chloride (0.15 1/1001)ClothTopicalShandong BaiHe Sanitary Products Co., Ltd.2020-11-23Not applicableUS flag
OKGO DisinfectantDidecyldimethylammonium chloride (0.5 mg/1mL)SprayTopicalHenan Seagood Medical Equipment Co., Ltd.2021-01-26Not applicableUS flag

Categories

ATC Codes
D08AJ06 — Didecyldimethylammonium chloride
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as tetraalkylammonium salts. These are organonitrogen compounds containing a quaternary ammonium substituted with four alkyl chains.
Kingdom
Organic compounds
Super Class
Organic nitrogen compounds
Class
Organonitrogen compounds
Sub Class
Quaternary ammonium salts
Direct Parent
Tetraalkylammonium salts
Alternative Parents
Organopnictogen compounds / Organic salts / Hydrocarbon derivatives / Amines / Organic cations
Substituents
Aliphatic acyclic compound / Amine / Hydrocarbon derivative / Organic cation / Organic salt / Organopnictogen compound / Tetraalkylammonium salt
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
Z7F472XQPA
CAS number
20256-56-8
InChI Key
JGFDZZLUDWMUQH-UHFFFAOYSA-N
InChI
InChI=1S/C22H48N/c1-5-7-9-11-13-15-17-19-21-23(3,4)22-20-18-16-14-12-10-8-6-2/h5-22H2,1-4H3/q+1
IUPAC Name
bis(decyl)dimethylazanium
SMILES
CCCCCCCCCC[N+](C)(C)CCCCCCCCCC

References

General References
Not Available
PubChem Compound
16958
PubChem Substance
46504890
ChemSpider
16067
RxNav
1425983
ChEMBL
CHEMBL1182247
ZINC
ZINC000014881137
PDBe Ligand
10A
Wikipedia
Didecyldimethylammonium_chloride
PDB Entries
1kph / 1kpi

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3RecruitingTreatmentBreast Cancer1
1, 2Not Yet RecruitingSupportive CareCancer Related Cognitive Decline / Non Metastatic Breast Cancer1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionTopical
SwabTopical
ClothExtracorporeal
PatchTopical
Solution, concentrateVaginal
GelTopical
LiquidTopical117 mg/60mL
SolutionTopical0.175 %
SolutionTopical0175 %
Aerosol, sprayTopical
ClothTopical0.15 1/1001
LiquidTopical
SprayTopical0.5 mg/1mL
ClothTopical
GelTopical0.2 g/100mL
LotionTopical
SprayTopical
SoapTopical
LiquidExtracorporeal1 mg/500mL
SprayTopical0.2 g/100mL
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility3.91e-06 mg/mLALOGPS
logP4.54ALOGPS
logP4.01ChemAxon
logS-8ALOGPS
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count18ChemAxon
Refractivity118.86 m3·mol-1ChemAxon
Polarizability47.15 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption-0.9316
Blood Brain Barrier+0.9507
Caco-2 permeable+0.7072
P-glycoprotein substrateSubstrate0.5383
P-glycoprotein inhibitor INon-inhibitor0.9627
P-glycoprotein inhibitor IINon-inhibitor0.801
Renal organic cation transporterNon-inhibitor0.5818
CYP450 2C9 substrateNon-substrate0.8615
CYP450 2D6 substrateNon-substrate0.6827
CYP450 3A4 substrateNon-substrate0.5266
CYP450 1A2 substrateNon-inhibitor0.8361
CYP450 2C9 inhibitorNon-inhibitor0.9569
CYP450 2D6 inhibitorNon-inhibitor0.9235
CYP450 2C19 inhibitorNon-inhibitor0.9237
CYP450 3A4 inhibitorNon-inhibitor0.9896
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9795
Ames testNon AMES toxic0.9608
CarcinogenicityCarcinogens 0.7426
BiodegradationReady biodegradable0.6956
Rat acute toxicity2.8056 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7692
hERG inhibition (predictor II)Inhibitor0.5
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Targets

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1. Phospholipid membrane
Kind
Group
Organism
Escherichia coli (strain K12)
Pharmacological action
Unknown
Curator comments
Literature suggests organisms other than E. coli also may have their cell membranes disrupted by drug.
References
  1. Yoshimatsu T, Hiyama K: Mechanism of the action of didecyldimethylammonium chloride (DDAC) against Escherichia coil and morphological changes of the cells. Biocontrol Sci. 2007 Sep;12(3):93-9. doi: 10.4265/bio.12.93. [Article]
  2. Lin W, Yuan D, Deng Z, Niu B, Chen Q: The cellular and molecular mechanism of glutaraldehyde-didecyldimethylammonium bromide as a disinfectant against Candida albicans. J Appl Microbiol. 2019 Jan;126(1):102-112. doi: 10.1111/jam.14142. Epub 2018 Nov 21. [Article]
Kind
Protein
Organism
Mycobacterium tuberculosis
Pharmacological action
Unknown
General Function
Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. In the absence of MmaA2, CmaA2 has a non-specific cis-cyclopropanating activity and is able to catalyze the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.
Specific Function
Cyclopropane-fatty-acyl-phospholipid synthase activity
Gene Name
cmaA2
Uniprot ID
P9WPB5
Uniprot Name
Cyclopropane mycolic acid synthase 2
Molecular Weight
34659.795 Da

Drug created at June 13, 2005 13:24 / Updated at September 28, 2021 21:54