Cyclopropane mycolic acid synthase 2

BE0001211ProteinMycobacterium tuberculosiscmaA2

Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfer of a methylene... It is acted on by 4 drugs in DrugBank.

Gene name
cmaA2
UniProtKB entry
P9WPB5Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
302 residues · 34,660 Da
Also known as
2.1.1.79 · AdoMet-MT · CFA synthase · cma2 · CMAS

Resolves to

Protein
UniProtP9WPB5UniProt nameCMAS2_MYCTU
Gene
NCBI Gene887264
Pharmacology
KEGGmtu:Rv0503c
Structure
PDB1KPIPDB3HEM
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cyclopropane mycolic acid synthase 2, how selective are they, and which programs against it are still in active trials?

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