Cycloleucine

DB04620ExperimentalSmall molecule

Cycloleucine is non-metabolisable amino acid formed by cyclization of leucine. It is also a specific and reversible inhibitor of nucleic acid methylation and widely used in biochemical experiments.

Mechanism: Pharmacologically active on Glutamate receptor ionotropic, NMDA 1
Curator reviewed
Formula / weight: C₆H₁₁NO₂ · 129.157 g/mol (avg)
Also known as: Cyclo-leucine · Cycloleucin
Code names: CB-1639 · WR 14,997 · X 201

Resolves to

Compound

UNII0TQU7668EICAS52-52-8ChEMBLCHEMBL295830ChEBI40547PubChem2901KEGGC03969

Structure

InChIKeyNILQLFBWTXNUOE-UHFFFAOYSA-NSMILESNC1(CCCC1)C(O)=O

Targets

Q05586GRIN1

What you can answer from here — as of September 16, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with Cycloleucine, and which of those have an active Phase 3 trial?

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