Glutamate receptor ionotropic, NMDA 1

BE0000365ProteinHumansGRIN1

Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:21376300, PubMed:26875626, PubMed:26919761, PubMed:28126851, PubMed:28228639, PubMed:36959261, PubMed:7679115, PubMed:7681588, PubMed:7685113). It is acted on by 23 drugs in DrugBank.

Gene name
GRIN1
UniProtKB entry
Q05586Swiss-Prot
Cellular location
Cell membrane
Residues / weight
938 residues · 105,372 Da
Also known as
GluN1 · Glutamate [NMDA] receptor subunit zeta-1 · hNR1 · N-methyl-D-aspartate receptor subunit NR1 · NMD-R1

Resolves to

Protein
UniProtQ05586UniProt nameNMDZ1_HUMAN
Gene
HGNCHGNC:4584NCBI Gene2902GenBank219920GeneCardsGRIN1
Pharmacology
IUPHAR/GtoPdb455KEGGhsa:2902
Structure
PDB10EYPDB10EZPDB10FD
Drugs

What you can answer from here — as of September 07, 2019

23DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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27GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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48+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamate receptor ionotropic, NMDA 1, how selective are they, and which programs against it are still in active trials?

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