DB05468ExperimentalSmall molecule
R411 is a non-steroid oral medicine for the treatment of asthma. It is not immunosuppressive, but blocks the activation and recruitment of cells involved in respiratory inflammation. It is a... It is a dual-acting competitive integrin antagonist (as compared to previously developed single integrin antagonists or SIAs) that prevents binding of V-CAM1 to either a4b1 or a4b7.
- Mechanism
- Curator reviewed
R411 prevents binding of V-CAM1 to either a4b1 or a4b7.
- Primary indication
- Investigated for use/treatment in asthma.Curator reviewed
Resolves to
Targets
What you can answer from here — as of April 02, 2025
1Protein targetEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with R411, and which of those have an active Phase 3 trial?
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