Integrin alpha-4

BE0000590ProteinHumansITGA4

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. It is acted on by 14 drugs in DrugBank.

Gene name
ITGA4
UniProtKB entry
P13612Swiss-Prot
Cellular location
Membrane
Residues / weight
1,032 residues · 114,899 Da
Also known as
CD49 antigen-like family member D · CD49D · Integrin alpha-IV · VLA-4 subunit alpha

Resolves to

Protein
UniProtP13612UniProt nameITA4_HUMAN
Gene
HGNCHGNC:6140NCBI Gene3676GenBank33946GeneCardsITGA4
Pharmacology
IUPHAR/GtoPdb2443KEGGhsa:3676
Structure
PDB3V4PPDB3V4VPDB4HKC
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
7Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
21GO termsFunction, process and component, as structured annotations
Sign in
4Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
45+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Integrin alpha-4, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In