DB05706InvestigationalSmall molecule
GPX-100 is an anthracycline anticancer drug that belongs to the family of drugs called antitumor antibiotics.
- Mechanism
- Curator reviewed
As an anthracycline, GPX-100 has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: GPX-100 forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.
- Primary indication
- Investigated for use/treatment in breast cancer and cancer/tumors (unspecified).Curator reviewed
- Formula / weight
- C27H31NO10 · 529.542 g/mol (avg)
- Code names
- GPX-100
Resolves to
Structure
InChIKey
RGVRUQHYQSORBY-JIGXQNLBSA-NSMILESCOC1=C2C(=O)C3=C(O)C4=C(C[C@@](O)(CCO)C[C@@H]4O[C@H]4C[C@H](N)[C@H](O)[C@H](C)O4)C(O)=C3C(=O)C2=CC=C1Targets
What you can answer from here — as of June 12, 2020
2Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with 13-deoxydoxorubicin, and which of those have an active Phase 3 trial?
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