DNA topoisomerase 2-alpha

BE0000742ProteinHumansTOP2A

Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken... It is acted on by 70 drugs in DrugBank.

Gene name
TOP2A
UniProtKB entry
P11388Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,531 residues · 174,384 Da
Also known as
5.6.2.2 · DNA topoisomerase II, alpha isozyme · TOP2

Resolves to

Protein
UniProtP11388UniProt nameTOP2A_HUMAN
Gene
HGNCHGNC:11989NCBI Gene7153GenBank292830GeneCardsTOP2A
Pharmacology
IUPHAR/GtoPdb2637KEGGhsa:7153
Structure
PDB1ZXMPDB1ZXNPDB4FM9
Drugs

What you can answer from here — as of September 07, 2019

70DrugsApproved to experimental, with action, bond type and pharmacological action
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10Clinical trialsTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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195+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA topoisomerase 2-alpha, how selective are they, and which programs against it are still in active trials?

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