Isosorbide is a vasodilator used for the prevention and treatment of angina pectoris due to coronary artery disease. It was previously used to reduce intraocular pressure. It was approved by the FDA in 1980, but has since been discontinued.
- Mechanism
- Curator reviewed · 1 reference
Isosorbide causes vascular relaxation, reducing systolic ophthalmic artery pressure (SOAP), systolic ocular perfusion pressure (SOPP).
- Primary indication
- Isosorbide was previously indicated for temporary reduction of intraocular pressure and used to interrupt an acute glaucoma attack, however, this is not a currently approved indication.Curator reviewed · 2 structured indications
- Formula / weight
- C6H10O4 · 146.1412 g/mol (avg)
- First approval
- United States, 2006
- Code names
- AT-101 · NSC-40725
Resolves to
Clinical / RWD
Structure
InChIKey
KLDXJTOLSGUMSJ-JGWLITMVSA-NSMILES[H][C@]1(O)CO[C@]2([H])[C@]([H])(O)CO[C@]12[H]What you can answer from here — as of May 15, 2021
1Protein targetEach mapped to UniProt, with action and pharmacological actionListed above
Which other approved drugs treat the same conditions as Isosorbide, and which companies have late-stage candidates in those indications?
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