- Vasodilating Agents
- Accession Number
- DBCAT003676 (DBCAT000516)
Drugs used to cause dilation of the blood vessels.
Drug Drug Description Nitric Oxide A vasodilating agent used in the treatment of hypoxic respiratory failure in premature neonates. Nitroprusside A direct acting vasodilator used to treat hypertension, to induce controlled hypotension to reduce postoperative bleeding, and to manage acute heart failure. Sildenafil A phosphodiesterase inhibitor used for the treatment of erectile dysfunction. Milrinone A PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure. Isradipine A dihydropyridine calcium channel blocker used for the treatment of hypertension. Theophylline A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. Diltiazem A calcium channel blocker used to treat hypertension and to manage chronic stable angina. Minoxidil An antihypertensive vasodilating agent used for resistant hypertension that is symptomatic or has caused end organ damage. Amlodipine A calcium channel blocker used to treat hypertension and angina. Nimodipine A calcium channel blocker used to improve neurological outcomes in patients with subarachnoid hemorrhage due to a ruptured intracranial aneurysm. Nisoldipine A calcium channel blocker used as monotherapy or combined with other drugs for the treatment of hypertension. Rosiglitazone A thiazolidinedione indicated as an adjunct to diet and exercise to maintain glycemic control in type 2 diabetes. Propranolol A non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma. Nicardipine A calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina. Niacin A B vitamin used to treat hypertriglyceridemia and pellagra. Adenosine A medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia. Dyphylline A theophylline derivative used to treat asthma, bronchospasm, and COPD. Verapamil A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension. Nicergoline An ergot derivative use for the treatment of symptoms associated with cerebrovascular abnormalities. Nitroglycerin A nitrate vasodilator used to treat or prevent angina, heart failure, hypertension, and anal fissures. Alprostadil A prostaglandin E1 agonist used for the treatment of erectile dysfunction and as an adjunct for its diagnosis. Tolazoline A vasodilator used to treat pulmonary artery anomalies. Fenoldopam A dopamine D1 receptor agonist used for the short term management of hypertension. Pentoxifylline A methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. Tadalafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Vardenafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction. Isosorbide dinitrate A vasodilator used to treat angina in coronary artery disease. Levosimendan A calcium sensitizer indicated to treat acutely decompensated severe chronic heart failure. Phenoxybenzamine An alpha adrenergic antagonist used to treat pheochromocytoma and episodes of hypertension and sweating. Pindolol A beta adrenoceptor antagonist used to treat hypertension, edema, ventricular tachycardias, and atrial fibrillation. Dipyridamole A phosphodiesterase inhibitor used to prevent postoperative thromboembolic events. Isosorbide mononitrate A nitrate used to prevent and treat angina and to treat angina caused by coronary artery disease. Felodipine A calcium channel blocker used to treat hypertension. Ergoloid mesylate A nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity. Nitrendipine A dihydropyridine calcium channel blocker indicated in the treatment of arterial hypertension. Perhexiline For the management of severe angina pectoris. Iloprost A synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH). Papaverine An alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". Nifedipine A dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension. Trimethaphan For the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies. Amiodarone A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. Diazoxide A non diuretic benzothiadiazine indicated for the management of hypoglycemia in patients who produce an excess of insulin caused by a variety of conditions. Carvedilol A non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. Cilostazol An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. Bepridil For the treatment of hypertension, and chronic stable angina (classic effort-associated angina). Hydralazine An antihypertensive agent used for the management of essential hypertension or severe hypertension associated with conditions requiring immediate action, heart failure, and pre-eclampsia or eclampsia . Mibefradil For the treatment of angina and high blood pressure. Theobromine theobromine is used as a vasodilator, a diuretic, and heart stimulant. And similar to caffeine, it may be useful in management of fatigue and orthostatic hypotension. Amrinone A positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure. Oxprenolol A non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety. Amyl Nitrite A fast acting vasodilator used for rapid relief of angina pectoris. Erythrityl tetranitrate For the prevention of angina. Colforsin Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities;... Resveratrol Being investigated for the treatment of Herpes labialis infections (cold sores). Acetylcholine A parasympathomimetic neurotransmitter used to induce miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Not Available Prenylamine Prenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias. Cyclandelate A vasodilator used for the treatment of various blood vessel diseases, such as claudication and arteriosclerosis. Flunarizine A selective calcium-entry blocker used as migraine prophylaxis in patients with severe and frequent episodes who have not responded adequately to more common treatments. Celiprolol A beta-blocker for the management of hypertension and angina pectoris. Nebivolol A beta blocking agent used to treat hypertension and aid in the management of heart failure. Enoximone A selective phosphodiesterase inhibitor indicated in the short term treatment of congestive heart failure. Beraprost For the treatment of pulmonary hypertension. Ibudilast For the treatment of multiple sclerosis, asthma, and cerebrovascular disease. Nylidrin A vasodilator used to treat patients with peripheral vascular disorders, and elderly patients with symptoms associated with organic mental disorders. Pentaerythritol tetranitrate Used for the treatment of angina pectoris . Calcitonin gene-related peptide Investigated for use/treatment in myocardial infarction, heart disease, and asthma. Dotarizine A calcium antagonist used to treat and prevent migraines. Tezosentan Investigated for use/treatment in congestive heart failure, liver disease, and heart disease. Xylometazoline A direct-acting alpha-adrenergic agonist used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds. Betahistine An antivertigo agent used for the reduction of episodes of vertigo association with Ménière's disease. Drotaverine A phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and genitourinary smooth muscle spasms. Pinacidil Pinacidil is a cyanoguanidine drug that acts by opening ATP-sensitive potassium channels, leading to peripheral vasodilatation of arterioles and decreasing peripheral vascular resistance. The above processes result in reduced blood... Isoxsuprine A beta-adrenergic agonist used in the symptomatic treatment of cerebrovascular insufficiency, peripheral vascular disease of arteriosclerosis obliterans, thromboangiitis obliterans (Buerger's disease) and Raynaud's disease. Inositol nicotinate A vasodilator and source of niacin found in dietary supplements. Indenolol Indenolol is a drug of the beta-adrenergic blocker class. Ifenprodil N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function.[A220118, A220128] NMDARs are heterotetramers that typically involve a dimer... Eperisone An antispasmodic that functions through voltage-gated channel blockade, notably with little to no sedation, effective in relaxing skeletal muscles and vascular smooth muscles. Trimetazidine A piperazine derivative indicated as an adjunct therapy in symptomatic treatment of stable angina pectoris. Xanthinol A vasodilatory niacin found in diet supplements. Moxisylyte By the WHO, moxisylyte is indicated for the symptomatic management of sequelae of cerebral infarction or hemorrhage. The cerebral infarction is characterized by the blockage of the artery either by... Trimazosin Trimazosin is a sympatholytic alpha blocker. Nicorandil A vasodilatory drug that functions through potassium channels and intracellular cGMP concentrations commonly used to treat angina. Benidipine A synthetic dihydropyridine calcium channel blocker used to treat hypertension and angina pectoris. Molsidomine A long-acting vasodilator used to treat angina pectoris, including in association with left heart failure and acute myocardial infarction. Trapidil Used in the treatment of chronic stable angina . Imolamine Imolamine is indicated for the treatment of angina pectoris. The hydrochloride form is used as a local anesthetic. Pimobendan Not Annotated Anisodamine Anisodamine has been investigated for the treatment of Intestinal Diseases. Bradykinin Bradykinin has been investigated for the basic science and treatment of Hypertension and Diabetes Type 2. Vinpocetine A synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease. Simendan Simendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure). Puerarin Puerarin has been investigated for the treatment of Alcohol Abuse. Dopexamine Dopexamine has been used in trials studying the diagnostic and treatment of Free Flap, Oral Cancer, Hypotension, Septic Shock, and Head and Neck Cancer. Urapidil A combination adrenergic antagonist and serotonin agonist given orally for the treatment of essential hypertension and intravenously in hypertensive emergencies. Bucindolol Bucindolol has been investigated in Heart Failure. Cafedrine Cafedrine is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation). Bamifylline A methylxanthine derivative indicated in the treatment of bronchial asthma and other conditions with bronchospasm. Bamethan Not Annotated Flosequinan Flosequinan was approved in the USA and the UK for a year prior to being withdrawn from the market due to increased mortality in chronic heart failure patients, found in... Hexobendine Hexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has... Carbocromen Carbocromen was marketed for use in Germany as a vasodilator, however, it has been discontinued due to the risk of arrhythmia development . Ibopamine A sympathomimetic, indicated in the induction of mydriasis and treatment of pos-surgical ocular hypotonia. Suloctidil Not Annotated Dihydroergocristine An ergot alkaloid used to delay progressive mental decline in conditions like Alzheimer's. Vincamine Vincamine is a monoterpenoid indole alkaloid obtained from the leaves of Vinca minor with a vasodilatory property. Studies indicate that vincamine increases the regional cerebral blood flow. Dihydroergocryptine A dopamine agonist indicated in the treatment of cerebrovascular diseases and atherosclerosis. Oxyfedrine Not Annotated Linsidomine Not Annotated Nicofuranose Not Annotated Endralazine Not Annotated Cadralazine Not Annotated Bencyclane A vasodilator agent found to be effective in a variety of peripheral circulation disorders. It has various other potentially useful pharmacological effects. Its mechanism may involve block of calcium channels. Buflomedil Not Annotated Naftidrofuryl A peripheral vasodilator indicated in the treatment of chronic venous ulcers. Butalamine Not Annotated Dilazep Not Annotated Cetiedil Not Annotated Lidoflazine Not Annotated Vinburnine Not Annotated Bufylline Not Annotated Etafenone Etafenone is a vasodilator. Treprostinil A prostacyclin vasodilator for the treatment of pulmonary arterial hypertension to relieve exercise associated symptoms and to prevent clinical deterioration after stopping epoprostenol. Bosentan A dual endothelin receptor antagonist used to treat pulmonary arterial hypertension. Epoprostenol A vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure. Ambrisentan A selective type A endothelin receptor antagonist used to treat primary pulmonary arterial hypertension and pulmonary arterial hypertension based on diagnostic classifications. Riociguat A stimulator of soluble guanylate cyclase indicated for the management of persistent or recurrent chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension. Macitentan An endothelin receptor antagonist used to manage pulmonary arterial hypertension to delay disease progression. Selexipag A non prostanoid IP prostacyclin receptor agonist used to treat pulmonary arterial hypertension. Udenafil A PDE5 inhibitor used to treat erectile dysfunction. Mirodenafil Mirodenafil has been used in trials studying the treatment and supportive care of Kidney Diseases, Urologic Diseases, Renal Insufficiency, Erectile Dysfunction, and Male Erectile Dysfunction. Avanafil A phosphodiesterase-5 (PDE5) inhibitor used to treat erectile dysfunction. Fostamatinib A spleen tyrosine kinase inhibitor used to treat chronic immune thrombocytopenia after attempting one other treatment. Lefradafiban For the treatment of unstable angina. Alferminogene tadenovec Investigated for use/treatment in angina, coronary artery disease, and heart disease. Ranolazine An anti-anginal drug used for the treatment of chronic angina. Propatyl nitrate Not Annotated Methylpropylpropanediol dinitrate Not Annotated Tenitramine Not Annotated Trolnitrate Not Annotated Agmatine Agmatine is being studied experimentally for several indications such as cardioprotection, diabetes, decreased kidney function, neuroprotection (stroke, severe CNS injuries, epilepsy, glaucoma, and neuropathic pain), and psychiatric conditions (depression, anxiety,... Aranidipine Aranidipine has been used for many years to treat angina pectoris and hypertension. Azelnidipine For the treatment of hypertension. Barnidipine A calcium channel blocker used to treat various forms of hypertension. Caroverine A calcium channel blocker indicated in the treatment of smooth muscle spasms, alcohol and drug withdrawal, and tinnitus. Cilnidipine A dihydropyridine calcium channel blocker with action on both N- and L-type calcium channels used to treat hypertension. Cinnarizine A drug used for the management of labyrinthine disorder symptoms, including vertigo, tinnitus, nystagmus, nausea, and vomiting. Clevidipine A dihydropyridine L-type calcium channel blocker used to lower blood pressure when oral antihypertensive therapy is not feasible or not desirable. Darodipine Darodipine is a calcium channel blocker. Efonidipine For the treatment of hypertension. Fendiline Fendiline is a coronary vasodilator which inhibits calcium function in muscle cells in excitation-contraction coupling. It has been proposed as an antiarrhythmic and antianginal agent. Fendiline is non-selective. Fish oil A source of essential fatty acids used as a source of calories in parenteral nutrition and as a dietary supplement. Gallopamil Gallopamil has been used in trials studying the treatment of Asthma. Lacidipine A lipophilic dihydropyridine calcium channel blocker with a slow onset of action used to treat hypertension. Lercanidipine A calcium channel blocker for the management of hypertension. Magnesium sulfate A drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany. Manidipine A dihydropyridine calcium channel blocker used to treat hypertension. Levomenthol An organic compound used to treat mild to moderate muscle and joint pain. Naftopidil Naftopidil has been investigated for the treatment of Disorder of Urinary Stent. Niguldipine Niguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties. Niludipine Niludipine is a calcium channel blocker. Nilvadipine A calcium channel blocker used to manage arterial hypertension. Otilonium A spasmolytic medication used to treat irritable bowel syndrome (IBS). Pinaverium A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract. Pregabalin An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Seletracetam Investigated for use/treatment in epilepsy. Terodiline Not Annotated Tetrahydropalmatine Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). Ziconotide An N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics. Prazosin An alpha-blocker that causes a decrease in total peripheral resistance and is used to treat hypertension. Ketamine A rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant. Phentolamine An alpha adrenergic antagonist used to reverse soft tissue anesthesia. Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Citalopram A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. Labetalol An alpha and beta adrenergic antagonist used to treat hypertension, angina, and sympathetic overactivity syndrome. Dexverapamil Not Annotated Dexpropranolol Not Available Nicotinyl alcohol A direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened gangrene. [PubChem] Fasudil Fasudil has been investigated in Carotid Stenosis. Isosorbide A vasodilator used for the prevention and treatment of angina pectoris due to coronary artery disease. It was previously used to reduce intraocular pressure. Nitrate Not Annotated Doxofylline A methylxanthine derivative used in chronic obstructive pulmonary disease, asthma, and bronchospasms. Angiotensin 1-7 TXA127 has been investigated for the treatment of Miscellaneous Peripheral Blood Cell Abnormalities. Cinepazide Cinepazide has been used in trials studying the treatment of Ischemic Stroke. Atrial natriuretic peptide Not Annotated Erythritol Erythritol is a four-carbon sugar that is found in algae, fungi, and lichens. It is twice as sweet as sucrose and can be used as a coronary vasodilator. Raubasine Not Annotated PACAP38 Not Available
- Drugs & Drug Targets