This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- SUVN-502
- DrugBank Accession Number
- DB06140
- Background
SUVN-502 is a novel, potent, safe, highly selective and orally active antagonist at a central nervous system serotonin receptor site 5-HT6 intended for treatment of cognitive disorders such as Alzheimer’s and Schizophrenia, an unmet medical need.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for SUVN-502 (DB06140)
- Weight
- Average: 478.41
Monoisotopic: 477.072176 - Chemical Formula
- C21H24BrN3O3S
- Synonyms
- Not Available
- External IDs
- SUVN-502
Pharmacology
- Indication
Investigated for use/treatment in neurologic disorders.
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Not Available
- Mechanism of action
Target Actions Organism U5-hydroxytryptamine receptor 6 Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
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Ingredient UNII CAS InChI Key SUVN-502 dimesylate BFE1VOB95D 1791396-46-7 LOZVXBFXRPRECW-UHFFFAOYSA-N SUVN-502 dimesylate monohydrate 9816MUD84T 1791396-45-6 XKDCUJBWVGDNSH-UHFFFAOYSA-N
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 8XZ281AO3G
- CAS number
- 701205-60-9
- InChI Key
- GWCYPEHWIZXYFZ-UHFFFAOYSA-N
- InChI
- InChI=1S/C21H24BrN3O3S/c1-23-9-11-24(12-10-23)14-16-15-25(20-8-7-17(28-2)13-18(16)20)29(26,27)21-6-4-3-5-19(21)22/h3-8,13,15H,9-12,14H2,1-2H3
- IUPAC Name
- 1-(2-bromobenzenesulfonyl)-5-methoxy-3-[(4-methylpiperazin-1-yl)methyl]-1H-indole
- SMILES
- COC1=CC=C2N(C=C(CN3CCN(C)CC3)C2=C1)S(=O)(=O)C1=CC=CC=C1Br
References
- General References
- Not Available
- External Links
- ChemSpider
- 8249313
- ChEMBL
- CHEMBL4117187
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Recruiting Treatment Agitation / Dementia of the Alzheimer's Type 1 2 Completed Treatment Alzheimer's Disease (AD) 1 Not Available No Longer Available Not Available Alzheimer's Disease (AD) / Cognitive Dysfunctions / Dementia 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0544 mg/mL ALOGPS logP 2.84 ALOGPS logP 3.4 Chemaxon logS -3.9 ALOGPS pKa (Strongest Basic) 7.79 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 54.78 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 118.84 m3·mol-1 Chemaxon Polarizability 46.57 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Serotonin receptor activity
- Specific Function
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor ...
- Gene Name
- HTR6
- Uniprot ID
- P50406
- Uniprot Name
- 5-hydroxytryptamine receptor 6
- Molecular Weight
- 46953.625 Da
Drug created at November 18, 2007 18:30 / Updated at March 24, 2023 19:19