5-hydroxytryptamine receptor 6

BE0000945ProteinHumansHTR6

G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:36989299, PubMed:37327704, PubMed:8522988). It is acted on by 43 drugs in DrugBank.

Gene name
HTR6
UniProtKB entry
P50406Swiss-Prot
Cellular location
Cell membrane
Residues / weight
440 residues · 46,954 Da
Also known as
5-HT-6 · 5-HT6 · Serotonin receptor 6

Resolves to

Protein
UniProtP50406UniProt name5HT6R_HUMAN
Gene
HGNCHGNC:5301NCBI Gene3362GenBank1162924GeneCardsHTR6
Pharmacology
IUPHAR/GtoPdb11KEGGhsa:3362
Structure
PDB7XTBPDB7YS6PDB8JLZ
Drugs

What you can answer from here — as of September 07, 2019

43DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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131+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5-hydroxytryptamine receptor 6, how selective are they, and which programs against it are still in active trials?

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