Pentaerythritol tetranitrate is the nitrate ester of pentaerythritol that possesses explosive properties. When mixed with a plasticizer, this chemical forms a plastic explosive. It is recognized by the FDA to... It is recognized by the FDA to be a coronary vasodilator in the treatment of heart conditions such as angina.
- Mechanism
- Curator reviewed · 1 reference
Pentaerythritol tetranitrate is the lipid soluble polyol ester of nitric acid belonging to the family of nitro-vasodilators. Pentaerythritol tetranitrate releases free nitric oxide (NO) after the denitration reaction, which triggers NO-dependent signaling transduction involving soluble guanylate cyclase (sGC). Nitric oxide binds reversibly to the ferrous-heme center of sGC, causing conformational change and activating the enzyme. This enzyme activation results in increased cellular concentrations of _cyclic guanosine monophosphate _(cGMP) within the vascular smooth muscle, resulting in vasodilation mediated by cGMP-dependent protein kinases. Additionally, this agent causes dose-dependent arterial and venous bed.
- Primary indication
- Used for the treatment of angina pectoris.Curator reviewed
- Formula / weight
- C5H8N4O12 · 316.1366 g/mol (avg)
- First approval
- Canada, 1961
- Also known as
- Corpent · PENT · PENTA · Pentaerithrityl tetranitrate · Penthrite
Resolves to
TZRXHJWUDPFEEY-UHFFFAOYSA-NSMILES[O-][N+](=O)OCC(CO[N+]([O-])=O)(CO[N+]([O-])=O)CO[N+]([O-])=OWhat you can answer from here — as of June 03, 2025
Which drugs share a target with Pentaerythritol tetranitrate, and which of those have an active Phase 3 trial?
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