Hemoglobin subunit alpha
Details
- Name
- Hemoglobin subunit alpha
- Kind
- protein
- Synonyms
- Alpha-globin
- Hemoglobin alpha chain
- Gene Name
- HBA1
- UniProtKB Entry
- P69905Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0036956|Hemoglobin subunit alpha MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHG KKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTP AVHASLDKFLASVSTVLTSKYR
- Number of residues
- 142
- Molecular Weight
- 15257.405
- Theoretical pI
- 9.09
- GO Classification
- Functionsorganic acid binding / oxygen carrier activityProcessescarbon dioxide transport / cellular oxidant detoxification / nitric oxide transportComponentsextracellular space
- General Function
- Involved in oxygen transport from the lung to the various peripheral tissues
- Specific Function
- heme binding
- Pfam Domain Function
- Globin (PF00042)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0010173|Hemoglobin subunit alpha (HBA1) ATGGTGCTGTCTCCTGCCGACAAGACCAACGTCAAGGCCGCCTGGGGTAAGGTCGGCGCG CACGCTGGCGAGTATGGTGCGGAGGCCCTGGAGAGGATGTTCCTGTCCTTCCCCACCACC AAGACCTACTTCCCGCACTTCGACCTGAGCCACGGCTCTGCCCAGGTTAAGGGCCACGGC AAGAAGGTGGCCGACGCGCTGACCAACGCCGTGGCGCACGTGGACGACATGCCCAACGCG CTGTCCGCCCTGAGCGACCTGCACGCGCACAAGCTTCGGGTGGACCCGGTCAACTTCAAG CTCCTAAGCCACTGCCTGCTGGTGACCCTGGCCGCCCACCTCCCCGCCGAGTTCACCCCT GCGGTGCACGCCTCCCTGGACAAGTTCCTGGCTTCTGTGAGCACCGTGCTGACCTCCAAA TACCGTTAA
- Chromosome Location
- 16
- Locus
- 16p13.3
- External Identifiers
- General References
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- Harano T, Harano K, Ueda S, Shibata S, Imai K, Ohba Y, Shinohara T, Horio S, Nishioka K, Shirotani H: Hemoglobin Kawachi [alpha 44 (CE2) Pro leads to Arg]: a new hemoglobin variant of high oxygen affinity with amino acid substitution at alpha 1 beta 2 contact. Hemoglobin. 1982;6(1):43-9. [Article]
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- Liu GY, Zhang GX, Nie SY, Luo HY, Teng YQ, Liu SP, Song M, Son L, Chen SS, Jia PC, Liang CC: A case of hemoglobin Iwata [alpha 87(F8)His leads to Arg] in China. Hemoglobin. 1983;7(3):279-82. [Article]
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- Ohba Y, Imai K, Uenaka R, Ami M, Fujisawa K, Itoh K, Hirakawa K, Miyaji T: Hb Miyano or alpha 41(C6)Thr----Ser: a new high oxygen affinity alpha chain variant found in an erythremic blood donor. Hemoglobin. 1989;13(7-8):637-47. [Article]
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- Abbes S, M'Rad A, Fitzgerald PA, Dormer P, Blouquit Y, Kister J, Galacteros F, Wajcman H: HB Al-Ain Abu Dhabi [alpha 18(A16)Gly----Asp]: a new hemoglobin variant discovered in an Emiratee family. Hemoglobin. 1992;16(5):355-62. [Article]
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- Curuk MA, Dimovski AJ, Baysal E, Gu LH, Kutlar F, Molchanova TP, Webber BB, Altay C, Gurgey A, Huisman TH: Hb Adana or alpha 2(59)(E8)Gly-->Asp beta 2, a severely unstable alpha 1-globin variant, observed in combination with the -(alpha)20.5 Kb alpha-thal-1 deletion in two Turkish patients. Am J Hematol. 1993 Dec;44(4):270-5. [Article]
- Wajcman H, Kister J, Galacteros F, Spielvogel A, Lin MJ, Vidugiris GJ, Hirsch RE, Friedman JM, Nagel RL: Hb Montefiore (126(H9)Asp-->Tyr). High oxygen affinity and loss of cooperativity secondary to C-terminal disruption. J Biol Chem. 1996 Sep 20;271(38):22990-8. [Article]
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- Brennan SO, Matthews JR: Hb Auckland [alpha 87(F8) His-->Asn]: a new mutation of the proximal histidine identified by electrospray mass spectrometry. Hemoglobin. 1997 Sep;21(5):393-403. [Article]
- Wajcman H, Kister J, M'Rad A, Soummer AM, Galacteros F: Hb Cemenelum [alpha 92 (FG4) Arg-->Trp]: a hemoglobin variant of the alpha 1/beta 2 interface that displays a moderate increase in oxygen affinity. Ann Hematol. 1994 Feb;68(2):73-6. [Article]
- Zeng YT, Huang SZ, Qiu XK, Cheng GC, Ren ZR, Jin QC, Chen CY, Jiao CT, Tang ZG, Liu RH, et al.: Hemoglobin Chongqing [alpha 2(NA2)Leu----Arg] and hemoglobin Harbin [alpha 16(A14)Lys----Met] found in China. Hemoglobin. 1984;8(6):569-81. [Article]
- Ayala S, Colomer D, Gelpi JL, Corrons JL: alpha-Thalassaemia due to a single codon deletion in the alpha1-globin gene. Computational structural analysis of the new alpha-chain variant. Mutations in brief no. 132. Online. Hum Mutat. 1998;11(5):412. [Article]
- Wilson JB, Webber BB, Plaseska D, de Alarcon PA, McMillan SK, Huisman TH: Hb Davenport or alpha 2(78)(EF7)Asn----His beta 2. Hemoglobin. 1990;14(6):599-605. [Article]
- Wilson JB, Webber BB, Kutlar A, Reese AL, McKie VC, Lutcher CL, Felice AE, Huisman TH: Hb Evans or alpha 262(E11)Val----Met beta 2; an unstable hemoglobin causing a mild hemolytic anemia. Hemoglobin. 1989;13(6):557-66. [Article]
- Cash FE, Monplaisir N, Goossens M, Liebhaber SA: Locus assignment of two alpha-globin structural mutants from the Caribbean basin: alpha Fort de France (alpha 45 Arg) and alpha Spanish Town (alpha 27 Val). Blood. 1989 Aug 1;74(2):833-5. [Article]
- Wajcman H, Kister J, Riou J, Galacteros F, Girot R, Maier-Redelsperger M, Nayudu NV, Giordano PC: Hb Godavari [alpha 95(G2)Pro-->Thr]: a neutral amino acid substitution in the alpha 1 beta 2 interface that modifies the electrophoretic mobility of hemoglobin. Hemoglobin. 1998 Jan;22(1):11-22. [Article]
- Huisman TH, Wilson JB, Gravely M, Hubbard M: Hemoglobin Grady: the first example of a variant with elongated chains due to an insertion of residues. Proc Natl Acad Sci U S A. 1974 Aug;71(8):3270-3. [Article]
- Orisaka M, Tajima T, Harano T, Harano K, Kushida Y, Imai K: A new alpha chain variant, Hb Hanamaki or alpha 2(139)(HC1)Lys----Glu beta 2, found in a Japanese family. Hemoglobin. 1992;16(1-2):67-71. [Article]
- Harano T, Harano K, Shibata S, Ueda S, Imai K, Seki M: HB Handa [alpha 90 (FG 2) Lys replaced by Met]: structure and biosynthesis of a new slightly higher oxygen affinity variant. Hemoglobin. 1982;6(4):379-89. [Article]
- Charache S, Mondzac AM, Gessner U: Hemoglobin Hasharon (alpha-2-47 his(CD5)beta-2): a hemoglobin found in low concentration. J Clin Invest. 1969 May;48(5):834-47. [Article]
- Fleming PJ, Sumner DR, Wyatt K, Hughes WG, Melrose WD, Jupe DM, Baikie MJ: Hemoglobin Hobart or alpha 20(Bl)His----Arg: a new alpha chain hemoglobin variant. Hemoglobin. 1987;11(3):211-20. [Article]
- Reed RE, Winter WP, Rucknagel DL: Haemoglobin inkster (alpha2 85aspartic acid leads to valine beta2) coexisting with beta-thalassaemia in a Caucasian family. Br J Haematol. 1974 Mar;26(3):475-84. [Article]
- Miyashita H, Hashimoto K, Mohri H, Ohokubo T, Harano T, Harano K, Imai K: Hb Kanagawa [alpha 40(C5)Lys----Met]: a new alpha chain variant with an increased oxygen affinity. Hemoglobin. 1992;16(1-2):1-10. [Article]
- Giordano PC, Harteveld CL, Streng H, Oosterwijk JC, Heister JG, Amons R, Bernini LF: Hb Kurdistan [alpha 47(CE5)Asp-->Tyr], a new alpha chain variant in combination with beta (0)-thalassemia. Hemoglobin. 1994 Jan;18(1):11-8. [Article]
- Harano T, Harano K, Imai K, Murakami T, Matsubara H: Hb Kurosaki [alpha 7(A5)Lys-->Glu]: a new alpha chain variant found in a Japanese woman. Hemoglobin. 1995 May-Jul;19(3-4):197-201. [Article]
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- Brimhall B, Jones RT, Schneider RG, Hosty TS, Tomlin G, Atkins R: Two new hemoglobins. Hemoglobin Alabama (beta39(C5)Gln leads to Lys) and hemoglobin Montgomery (alpha 48(CD 6) Leu leads to Arg). Biochim Biophys Acta. 1975 Jan 30;379(1):28-32. [Article]
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- Zeng YT, Huang SZ, Zhou XD, Qiu XK, Dong QY, Li MY, Bai JH: Hb Shenyang (alpha 26 (B7) Ala replaced by Glu): a new unstable variant found in China. Hemoglobin. 1982;6(6):625-8. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Iron Dextran approved, vet_approved yes target activator Details 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine experimental yes target inhibitor Details 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine experimental yes target inhibitor Details 4-Carboxycinnamic Acid experimental yes target inhibitor Details Sebacic acid experimental yes target inhibitor Details 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID experimental unknown target Details 2,6-dicarboxynaphthalene experimental yes target inhibitor Details Efaproxiral investigational yes target inhibitor Details Trimesic acid experimental yes target inhibitor Details Sodium ferric gluconate complex approved unknown target binding Details Nitrous acid approved, investigational yes target oxidizer Details Iron approved yes target activator Details Copper approved, investigational unknown target Details Zinc approved, investigational unknown target Details Ferric pyrophosphate experimental yes target binder Details Ferric pyrophosphate citrate approved, investigational yes target binder Details Pentaerythritol tetranitrate approved yes target agonist Details Zinc acetate approved, investigational unknown target Details Ferrous gluconate approved unknown target Details Ferrous succinate approved unknown target Details Ferrous ascorbate approved unknown target Details Ferrous fumarate approved unknown target Details Ferrous glycine sulfate approved unknown target Details Zinc chloride approved, investigational unknown target inducer Details Voxelotor approved, investigational yes target binder Details Ferric derisomaltose approved unknown target binder Details Ferrous sulfate anhydrous approved yes target binder Details Zinc sulfate, unspecified form approved, experimental unknown target inducer Details Oxygen approved, vet_approved unknown carrier binder Details Ferroheme investigational yes target inhibitor Details 2,2-Dimethylbutyrate investigational yes target inducer Details Deferitazole investigational yes target modulator Details 5-Hydroxymethylfurfural investigational yes target modulator Details