DB06184InvestigationalSmall molecule
A second-generation synthetic antisense oligonucleotide with potential antineoplastic activity. AEG35156 selectively blocks the cellular expression of X-linked inhibitor of apoptosis protein (XIAP), a pivotal inhibitor of apoptosis that is overexpressed... This agent reduces total levels of XIAP in tumor cells, working synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis.
- Primary indication
- Investigated for use/treatment in cancer/tumors (unspecified) and leukemia (myeloid).Curator reviewed
- Code names
- GEM-640
Resolves to
Compound
Targets
What you can answer from here — as of June 12, 2020
Which drugs share a target with AEG35156, and which of those have an active Phase 3 trial?
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