E3 ubiquitin-protein ligase XIAP

BE0001156ProteinHumansXIAP

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis (PubMed:11257230, PubMed:11257231, PubMed:11447297, PubMed:12121969, PubMed:12620238,... It is acted on by 14 drugs in DrugBank.

Gene name
XIAP
UniProtKB entry
P98170Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
497 residues · 56,684 Da
Also known as
2.3.2.27 · API3 · Baculoviral IAP repeat-containing protein 4 · BIRC4 · hIAP-3

Resolves to

Protein
UniProtP98170UniProt nameXIAP_HUMAN
Gene
HGNCHGNC:592NCBI Gene331GenBank1184320GeneCardsXIAP
Pharmacology
IUPHAR/GtoPdb2790KEGGhsa:331
Structure
PDB1C9QPDB1F9XPDB1G3F
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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9Clinical trialsTrials of drugs acting on it, by phase and status
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15GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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56+ReferencesStructured and connected to the statements they support
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Which approved drugs act on E3 ubiquitin-protein ligase XIAP, how selective are they, and which programs against it are still in active trials?

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