SPC2968

SPC2968 is a potent inhibitor of hypoxia inducible transcription factor (HIF-1±), which serves as the key sensor of cellular hypoxia in response to which it transcriptionally up-regulates a host of genes that play important roles in promotion of cancers, including angiogenesis, apoptosis, cell migration and metastasis. HIF-1± protein is essentially undetectable in normal cells, but reaches high intracellular concentrations in a variety of cancers where it is strongly correlated with poor prognosis and resistance to therapy. SPC2968 thus has the potential to become a broad, multiple mode-of-action and highly cancer cell selective drug. [Santaris Pharmaceuticals Website]