Hypoxia-inducible factor 1-alpha

BE0002374ProteinHumansHIF1A

Functions as a master transcriptional regulator of the adaptive response to hypoxia (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100). It is acted on by 11 drugs in DrugBank.

Gene name
HIF1A
UniProtKB entry
Q16665Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
826 residues · 92,670 Da
Also known as
ARNT-interacting protein · Basic-helix-loop-helix-PAS protein MOP1 · BHLHE78 · Class E basic helix-loop-helix protein 78 · HIF-1-alpha

Resolves to

Protein
UniProtQ16665UniProt nameHIF1A_HUMAN
Gene
HGNCHGNC:4910NCBI Gene3091GeneCardsHIF1A
Pharmacology
KEGGhsa:3091
Structure
PDB1H2KPDB1H2LPDB1H2M
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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25Clinical trialsTrials of drugs acting on it, by phase and status
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44GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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73+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hypoxia-inducible factor 1-alpha, how selective are they, and which programs against it are still in active trials?

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