DB06359InvestigationalGene Therapies
Investigated for use/treatment in cancer/tumors (unspecified) and leukemia (myeloid).
- Mechanism
- Curator reviewed
G4460 targets an oncogene product known as c-myb, which is a protein that directly binds to cellular DNA. C-myb is believed to regulate the expression of other genes that are involved in the growth and differentiation of cancer cells. Over-expression of c-myb blocks differentiation, promotes proliferation, and decreases apoptosis.
- Primary indication
- Investigated for use/treatment in cancer/tumors (unspecified) and leukemia (myeloid).Curator reviewed
- Also known as
- c-myb antisense oligodeoxynucleotide · c-myb antisense oligonucleotide G4460
- Code names
- G 4460 · INX 3001 · INXC 3001 · LR3001
Resolves to
Targets
What you can answer from here — as of April 23, 2025
1Protein targetEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with G4460, and which of those have an active Phase 3 trial?
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