Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- ANA975
- DrugBank Accession Number
- DB06490
- Background
ANA975 is a toll-like receptor 7 agonist that is developed for the treatment of hepatitis C.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for ANA975 (DB06490)
- Weight
- Average: 384.36
Monoisotopic: 384.073970045 - Chemical Formula
- C14H16N4O7S
- Synonyms
- ((2R,3R,4R,5R)-4-ACETOXY-5-(5-AMINO-2-OXO-THIAZOLO(4,5-D)PYRIMIDIN-3-YL)-2-(HYDROXYMETHYL)TETRAHYDROFURAN-3-YL) ACETATE
- AN 975
- ISOTORABINE
- THIAZOLO(4,5-D)PYRIMIDIN-2(3H)-ONE, 5-AMINO-3-(2,3-DI-O-ACETYL-.BETA.-D-RIBOFURANOSYL)-
Pharmacology
- Indication
Investigated for use/treatment in hepatitis (viral, C), infectious and parasitic disease (unspecified), and viral infection.
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Not Available
- Mechanism of action
ANA975 is an oral prodrug of isatoribine, a small molecule toll-like receptor 7 (TLR-7) agonist. Isatoribine is a patented nucleoside analog Anadys is developing for the treatment of HCV infection. Isatoribine is one of a new class of drugs being developed by Anadys to regulate innate immunity, combat HCV infection and overcome limitations of current therapies. Anadys believes isatoribine interacts with a specific receptor, Toll-like receptor 7, or TLR7, that is present on certain immune system cells.
Target Actions Organism UToll-like receptor 7 Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 5UN5EF99CE
- CAS number
- 847453-47-8
- InChI Key
- ZWELIJXAKMASLK-UGKPPGOTSA-N
- InChI
- InChI=1S/C14H16N4O7S/c1-5(20)23-9-7(4-19)25-12(10(9)24-6(2)21)18-11-8(26-14(18)22)3-16-13(15)17-11/h3,7,9-10,12,19H,4H2,1-2H3,(H2,15,16,17)/t7-,9-,10-,12-/m1/s1
- IUPAC Name
- SMILES
- [H][C@]1(CO)O[C@@]([H])(N2C(=O)SC3=CNC(=N)N=C23)[C@]([H])(OC(C)=O)[C@]1([H])OC(C)=O
References
- General References
- Not Available
- External Links
- ChemSpider
- 9409523
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:12738885, PubMed:27742543, PubMed:31608988, PubMed:32706371, PubMed:35477763). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:27742543, PubMed:32706371)
- Specific Function
- Double-stranded rna binding
- Gene Name
- TLR7
- Uniprot ID
- Q9NYK1
- Uniprot Name
- Toll-like receptor 7
- Molecular Weight
- 120920.8 Da
Drug created at March 19, 2008 16:35 / Updated at August 10, 2024 03:44