Toll-like receptor 7

BE0000155ProteinHumansTLR7

Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612). It is acted on by 22 drugs in DrugBank.

Gene name
TLR7
UniProtKB entry
Q9NYK1Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
1,049 residues · 120,921 Da

Resolves to

Protein
UniProtQ9NYK1UniProt nameTLR7_HUMAN
Gene
HGNCHGNC:15631NCBI Gene51284GenBank7330281GeneCardsTLR7
Pharmacology
IUPHAR/GtoPdb1757KEGGhsa:51284
Structure
PDB7CYN
Drugs

What you can answer from here — as of September 07, 2019

22DrugsApproved to experimental, with action, bond type and pharmacological action
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8Clinical trialsTrials of drugs acting on it, by phase and status
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22GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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67+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Toll-like receptor 7, how selective are they, and which programs against it are still in active trials?

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