Mevastatin or compactin is a cholesterol-lowering agent isolated from Penicillium citinium. It was the first discovered agent belonging to the class of cholesterol-lowering medications known as statins. During a search... During a search for antibiotic compounds produced by fungi in 1971, Akira Endo at Sankyo Co.
- Mechanism
- Curator reviewed
Mevastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. Mevastatin is a prodrug that is activated in vivo via hydrolysis of the lactone ring. The hydrolyzed lactone ring mimics the tetrahedral intermediate produced by the reductase allowing the agent to bind with 10,000 times greater affinity than its natural substrate. The bicyclic portion of mevastatin binds to the coenzyme A portion of the active site.
- Primary indication
- Not used therapeutically due to its many side effects.Curator reviewed
- Formula / weight
- C23H34O5 · 390.52 g/mol (avg)
- Also known as
- Compactin
- Code names
- Antibiotic ML 236B · CS 500 · ML-236B
Resolves to
AJLFOPYRIVGYMJ-INTXDZFKSA-NSMILES[H][C@]12[C@H](CCC=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CCWhat you can answer from here — as of February 21, 2021
Which drugs share a target with Mevastatin, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account