3-hydroxy-3-methylglutaryl-coenzyme A reductase

BE0000574ProteinHumansHMGCR

Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544). It is acted on by 33 drugs in DrugBank.

Gene name
HMGCR
UniProtKB entry
P04035Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
888 residues · 97,475 Da
Also known as
1.1.1.34 · HMG-CoA reductase

Resolves to

Protein
UniProtP04035UniProt nameHMDH_HUMAN
Gene
HGNCHGNC:5006NCBI Gene3156GenBank306865GeneCardsHMGCR
Pharmacology
IUPHAR/GtoPdb639KEGGhsa:3156
Structure
PDB1DQ8PDB1DQ9PDB1DQA
Drugs

What you can answer from here — as of September 07, 2019

33DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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120+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3-hydroxy-3-methylglutaryl-coenzyme A reductase, how selective are they, and which programs against it are still in active trials?

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