CHIR-124

DB06852ExperimentalSmall molecule

CHIR-124 is a potent inhibitor of Chk1 that potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo.

Chemical structure of CHIR-124
Formula / weight
C23H22ClN5O · 419.907 g/mol (avg)
Code names
CHIR-124

Resolves to

Compound
UNII5K64W8EU3ECAS405168-58-3ChEMBLCHEMBL377312PubChem11502647
Structure
InChIKeyMOVBBVMDHIRCTG-LJQANCHMSA-NSMILESClC1=CC2=C(NC(=O)C(C3=NC4=CC=CC=C4N3)=C2N[C@@H]2CN3CCC2CC3)C=C1
Targets
O14757CHEK1

What you can answer from here — as of June 12, 2020

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
3+ReferencesStructured and connected to the statements they support
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