Serine/threonine-protein kinase Chk1

BE0003382ProteinHumansCHEK1

Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856, PubMed:32357935). It is acted on by 50 drugs in DrugBank.

Gene name
CHEK1
UniProtKB entry
O14757Swiss-Prot
Cellular location
Nucleus
Residues / weight
476 residues · 54,433 Da
Also known as
2.7.11.1 · Cell cycle checkpoint kinase · Checkpoint kinase-1 · CHK1 · CHK1 checkpoint homolog

Resolves to

Protein
UniProtO14757UniProt nameCHK1_HUMAN
Gene
HGNCHGNC:1925NCBI Gene1111GeneCardsCHEK1
Pharmacology
IUPHAR/GtoPdb1987KEGGhsa:1111
Structure
PDB10HYPDB10HZPDB10IA
Drugs

What you can answer from here — as of September 07, 2019

50DrugsApproved to experimental, with action, bond type and pharmacological action
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10Clinical trialsTrials of drugs acting on it, by phase and status
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18GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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185+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase Chk1, how selective are they, and which programs against it are still in active trials?

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