Spinosad

DB08823ApprovedVet approvedSmall moleculePediculicides

Spinosad is a pediculicide used topically to treat head lice. Spinosad is an insecticide based on a compound found in S. spinosa, a bacterial species.

Mechanism: Spinosad is a mixture of spinosyn A and spinosyn D in a 5:1 ratio. This combination causes neuronal hyperexcitation through mostly alteration of nicotinic acetylcholine receptors, which ultimately leads to lice paralysis and death.
Curator reviewed
Primary indication: Spinosad is indicated for the topical treatment of head lice infestation in adult and pediatric patients ≥6 months old.Curator reviewed · 2 structured indications
Formula / weight: C₈₃H₁₃₂N₂O₂₀ · 1477.963 g/mol (avg)
First approval: United States, 2011
Code names: DE-105 · LY-232105 · PP-105 · XDE-105
Brand names: Natroba

Resolves to

Compound

UNIIXPA88EAP6VCAS168316-95-8ChEMBLCHEMBL2040681ChEBI39211PubChem17754356KEGGD09384

Clinical / RWD

RxNorm299081

Structure

InChIKeyJFLRKDZMHNBDQS-SGSTVUCESA-NSMILES

[H][C@]1(C[C@@]2([H])C=C[C@@]3([H])[C@]4([H])CC(=O)O[C@@]([H])(CC)CCC[C@]([H])(O[C@@]5([H])CC[C@]([H])(N(C)C)[C@@]([H])(C)O5)[C@@]([H])(C)C(=O)C4=C[C@@]3([H])[C@]2([H])C1)O[C@]1([H])O[C@@]([H])(C)[C@]([H])(OC)[C@@]([H])(OC)[C@@]1([H])OC.[H][C@]1(C[C@@]2([H])C(C)=C[C@@]3([H])[C@]4([H])CC(=O)O[C@@]([H])(CC)CCC[C@]([H])(O[C@@]5([H])CC[C@]([H])(N(C)C)[C@@]([H])(C)O5)[C@@]([H])(C)C(=O)C4=C[C@@]3([H])[C@]2([H])C1)O[C@]1([H])O[C@@]([H])(C)[C@]([H])(OC)[C@@]([H])(OC)[C@@]1([H])OC

Targets

P36544CHRNA7

What you can answer from here — as of August 31, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

10Clinical trialsPhase, status and sponsor resolved per trial

2Structured indicationsCondition, population, route and combination as fields, not prose

11Marketed productsAcross 2 countries and 5 labellers

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with Spinosad, and which of those have an active Phase 3 trial?

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