Neuronal acetylcholine receptor subunit alpha-7
Details
- Name
- Neuronal acetylcholine receptor subunit alpha-7
- Kind
- protein
- Synonyms
- NACHRA7
- Gene Name
- CHRNA7
- UniProtKB Entry
- P36544Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0004597|Neuronal acetylcholine receptor subunit alpha-7 MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI ICTIGILMSAPNFVEAVSKDFA
- Number of residues
- 502
- Molecular Weight
- 56448.925
- Theoretical pI
- 6.44
- GO Classification
- Functionsacetylcholine-gated monoatomic cation-selective channel activity / amyloid-beta binding / calcium channel activity / monoatomic ion channel activityProcessesacetylcholine receptor signaling pathway / dendrite arborization / dendritic spine organization / intracellular calcium ion homeostasis / learning or memory / modulation of excitatory postsynaptic potential / monoatomic ion transmembrane transport / monoatomic ion transport / negative regulation of amyloid-beta formation / positive regulation of amyloid-beta formation / positive regulation of cell population proliferation / positive regulation of CoA-transferase activity / positive regulation of ERK1 and ERK2 cascade / positive regulation of excitatory postsynaptic potential / positive regulation of long-term synaptic potentiation / positive regulation of MAPK cascade / positive regulation of protein metabolic process / positive regulation of protein phosphorylation / regulation of amyloid fibril formation / regulation of amyloid precursor protein catabolic process / response to acetylcholine / response to amyloid-beta / sensory processing / short-term memory / synapse organizationComponentsmembrane / plasma membrane raft / postsynapse
- General Function
- After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin
- Specific Function
- acetylcholine binding
- Pfam Domain Function
- Signal Regions
- 1-22
- Transmembrane Regions
- 231-255 262-280 296-317 470-490
- Cellular Location
- Postsynaptic cell membrane
- Gene sequence
>lcl|BSEQ0020606|Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7) ATGCGCTGCTCGCCGGGAGGCGTCTGGCTGGCGCTGGCCGCGTCGCTCCTGCACGTGTCC CTGCAAGGCGAGTTCCAGAGGAAGCTTTACAAGGAGCTGGTCAAGAACTACAATCCCTTG GAGAGGCCCGTGGCCAATGACTCGCAACCACTCACCGTCTACTTCTCCCTGAGCCTCCTG CAGATCATGGACGTGGATGAGAAGAACCAAGTTTTAACCACCAACATTTGGCTGCAAATG TCTTGGACAGATCACTATTTACAGTGGAATGTGTCAGAATATCCAGGGGTGAAGACTGTT CGTTTCCCAGATGGCCAGATTTGGAAACCAGACATTCTTCTCTATAACAGTGCTGATGAG CGCTTTGACGCCACATTCCACACTAACGTGTTGGTGAATTCTTCTGGGCATTGCCAGTAC CTGCCTCCAGGCATATTCAAGAGTTCCTGCTACATCGATGTACGCTGGTTTCCCTTTGAT GTGCAGCACTGCAAACTGAAGTTTGGGTCCTGGTCTTACGGAGGCTGGTCCTTGGATCTG CAGATGCAGGAGGCAGATATCAGTGGCTATATCCCCAATGGAGAATGGGACCTAGTGGGA ATCCCCGGCAAGAGGAGTGAAAGGTTCTATGAGTGCTGCAAAGAGCCCTACCCCGATGTC ACCTTCACAGTGACCATGCGCCGCAGGACGCTCTACTATGGCCTCAACCTGCTGATCCCC TGTGTGCTCATCTCCGCCCTCGCCCTGCTGGTGTTCCTGCTTCCTGCAGATTCCGGGGAG AAGATTTCCCTGGGGATAACAGTCTTACTCTCTCTTACCGTCTTCATGCTGCTCGTGGCT GAGATCATGCCCGCAACATCCGATTCGGTACCATTGATAGCCCAGTACTTCGCCAGCACC ATGATCATCGTGGGCCTCTCGGTGGTGGTGACAGTGATCGTGCTGCAGTACCACCACCAC GACCCCGACGGGGGCAAGATGCCCAAGTGGACCAGAGTCATCCTTCTGAACTGGTGCGCG TGGTTCCTGCGAATGAAGAGGCCCGGGGAGGACAAGGTGCGCCCGGCCTGCCAGCACAAG CAGCGGCGCTGCAGCCTGGCCAGTGTGGAGATGAGCGCCGTGGCGCCGCCGCCCGCCAGC AACGGGAACCTGCTGTACATCGGCTTCCGCGGCCTGGACGGCGTGCACTGTGTCCCGACC CCCGACTCTGGGGTAGTGTGTGGCCGCATGGCCTGCTCCCCCACGCACGATGAGCACCTC CTGCACGGCGGGCAACCCCCCGAGGGGGACCCGGACTTGGCCAAGATCCTGGAGGAGGTC CGCTACATTGCCAACCGCTTCCGCTGCCAGGACGAAAGCGAGGCGGTCTGCAGCGAGTGG AAGTTCGCCGCCTGTGTGGTGGACCGCCTGTGCCTCATGGCCTTCTCGGTCTTCACCATC ATCTGCACCATCGGCATCCTGATGTCGGCTCCCAACTTCGTGGAGGCCGTGTCCAAAGAC TTTGCGTAA
- Chromosome Location
- 15
- Locus
- 15q13.2
- External Identifiers
Resource Link UniProtKB ID P36544 UniProtKB Entry Name ACHA7_HUMAN GenBank Protein ID 496607 GenBank Gene ID X70297 GeneCard ID CHRNA7 GenAtlas ID CHRNA7 HGNC ID HGNC:1960 PDB ID(s) 2MAW, 5AFH, 5AFJ, 5AFK, 5AFL, 5AFM, 5AFN, 7EKI, 7EKP, 7EKT, 7KOO, 7KOQ, 7KOX, 7RPM, 8C9X, 8CAU, 8CE4, 8CI1, 8CI2, 8F4V, 8P1H, 8UT1, 8UTB, 8UZJ, 8V80, 8V82, 8V86, 8V88, 8V89, 8V8A, 8V8C, 8V8D KEGG ID hsa:1139 IUPHAR/Guide To Pharmacology ID 468 NCBI Gene ID 89832 - General References
- Peng X, Katz M, Gerzanich V, Anand R, Lindstrom J: Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes. Mol Pharmacol. 1994 Mar;45(3):546-54. [Article]
- Elliott KJ, Ellis SB, Berckhan KJ, Urrutia A, Chavez-Noriega LE, Johnson EC, Velicelebi G, Harpold MM: Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. J Mol Neurosci. 1996 Fall;7(3):217-28. [Article]
- Groot Kormelink PJ, Luyten WH: Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32. FEBS Lett. 1997 Jan 6;400(3):309-14. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. [Article]
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- Chini B, Raimond E, Elgoyhen AB, Moralli D, Balzaretti M, Heinemann S: Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7). Genomics. 1994 Jan 15;19(2):379-81. [Article]
- Riley B, Williamson M, Collier D, Wilkie H, Makoff A: A 3-Mb map of a large Segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. Genomics. 2002 Feb;79(2):197-209. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Nicotine approved yes target agonist Details GTS-21 investigational yes target agonist Details RPI-78M investigational unknown target Details Varenicline approved, investigational unknown target agonist Details Bradanicline investigational yes target agonist Details Amobarbital approved, illicit unknown target antagonist Details Pentobarbital approved, investigational, vet_approved unknown target antagonist Details Butalbital approved, illicit unknown target antagonist Details Talbutal approved, illicit unknown target antagonist Details Secobarbital approved, vet_approved unknown target antagonist Details Metharbital withdrawn unknown target antagonist Details Thiopental approved, vet_approved unknown target antagonist Details Primidone approved, vet_approved unknown target antagonist Details Methylphenobarbital approved unknown target antagonist Details Phenobarbital approved, investigational unknown target antagonist Details Aprobarbital experimental, illicit unknown target antagonist Details Butobarbital approved, illicit unknown target antagonist Details Heptabarbital experimental unknown target antagonist Details Hexobarbital experimental unknown target antagonist Details Barbital illicit unknown target antagonist Details Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione experimental, illicit yes target antagonist Details Memantine approved, investigational unknown target antagonist Details Tenocyclidine experimental, illicit, investigational unknown target antagonist Details Tramadol approved, investigational unknown target antagonist Details Dextromethorphan approved unknown target antagonist Details Cytisine experimental unknown target agonist Details Ethanol approved unknown target Details Lobeline investigational unknown target Details Mecamylamine approved, investigational unknown target Details Tubocurarine approved unknown target Details Acetylcholine approved, investigational unknown target Details Choline approved, nutraceutical unknown target Details Epibatidine experimental unknown target Details Cannabidiol approved, investigational unknown target Details Ketamine approved, vet_approved yes target antagonist Details Choline salicylate approved, nutraceutical unknown target Details Nabiximols investigational unknown target Details Medical Cannabis experimental, investigational unknown target Details Encenicline investigational yes target partial agonist Details Amantadine approved unknown target antagonist Details Methadone approved yes target agonist Details Galantamine approved yes target allosteric modulator Details AZD-0328 investigational yes target modulator Details AVL-3288 investigational yes target modulator Details JNJ-39393406 investigational yes target modulator Details Facinicline investigational yes target antagonist Details TC-6987 investigational yes target modulator Details Ziprasidone approved yes target binder Details Alcuronium experimental yes target inhibitor Details