Neuronal acetylcholine receptor subunit alpha-7

BE0002341ProteinHumansCHRNA7

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate... It is acted on by 60 drugs in DrugBank.

Gene name
CHRNA7
UniProtKB entry
P36544Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
502 residues · 56,449 Da
Also known as
nAChR7 · NACHRA7 · Nicotinic acetylcholine receptor subunit alpha-7

Resolves to

Protein
UniProtP36544UniProt nameACHA7_HUMAN
Gene
HGNCHGNC:1960NCBI Gene89832GenBank496607GeneCardsCHRNA7
Pharmacology
IUPHAR/GtoPdb468KEGGhsa:1139
Structure
PDB2MAWPDB5AFHPDB5AFJ
Drugs

What you can answer from here — as of September 07, 2019

60DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
42GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
167+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Neuronal acetylcholine receptor subunit alpha-7, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In