Identification
- Generic Name
- Cloperastine
- DrugBank Accession Number
- DB09002
- Background
Cloperastine is a cough suppressant that acts on the central nervous system.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Cloperastine (DB09002)
- Weight
- Average: 329.864
Monoisotopic: 329.154642102 - Chemical Formula
- C20H24ClNO
- Synonyms
- Cloperastina
- Cloperastine
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
- Associated Therapies
- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Cloperastine hydrochloride PI4N7C63ND 14984-68-0 UNPLRYRWJLTVAE-UHFFFAOYSA-N - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Facol Classic One Cloperastine hydrochloride (8 mg/1) + Acetaminophen (200 mg/1) + Chlorpheniramine maleate (1.25 mg/1) + DL-Methylephedrine hydrochloride (12.5 mg/1) + Guaifenesin (41.6 mg/1) + Pseudoephedrine hydrochloride (15 mg/1) Capsule Oral OASIS TRADING 2018-11-22 Not applicable US 
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Facol Classic One Cloperastine hydrochloride (8 mg/1) + Acetaminophen (200 mg/1) + Chlorpheniramine maleate (1.25 mg/1) + DL-Methylephedrine hydrochloride (12.5 mg/1) + Guaifenesin (41.6 mg/1) + Pseudoephedrine hydrochloride (15 mg/1) Capsule Oral OASIS TRADING 2018-11-22 Not applicable US
Categories
- ATC Codes
- R05DB21 — Cloperastine
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Diphenylmethanes
- Direct Parent
- Diphenylmethanes
- Alternative Parents
- Benzylethers / Chlorobenzenes / Piperidines / Aryl chlorides / Trialkylamines / Dialkyl ethers / Azacyclic compounds / Organopnictogen compounds / Organochlorides / Hydrocarbon derivatives
- Substituents
- Amine / Aromatic heteromonocyclic compound / Aryl chloride / Aryl halide / Azacycle / Benzylether / Chlorobenzene / Dialkyl ether / Diphenylmethane / Ether
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 69M5L7BXEK
- CAS number
- 3703-76-2
- InChI Key
- FLNXBVJLPJNOSI-UHFFFAOYSA-N
- InChI
- InChI=1S/C20H24ClNO/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22/h1,3-4,7-12,20H,2,5-6,13-16H2
- IUPAC Name
- 1-{2-[(4-chlorophenyl)(phenyl)methoxy]ethyl}piperidine
- SMILES
- ClC1=CC=C(C=C1)C(OCCN1CCCCC1)C1=CC=CC=C1
References
- Synthesis Reference
Merck Index 2358.
- General References
- Serrano M, Sanz-Cuesta M, Villaronga M, Hayek LF, Perez-Duenas B: Cloperastine-based cough syrup and acute dystonic reactions. Dev Med Child Neurol. 2012 Mar;54(3):287. doi: 10.1111/j.1469-8749.2011.04105.x. [Article]
- External Links
- KEGG Drug
- D03557
- PubChem Compound
- 2805
- PubChem Substance
- 310264962
- ChemSpider
- 2703
- BindingDB
- 50237287
- 2104180
- ChEBI
- 94448
- ChEMBL
- CHEMBL415087
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Cloperastine
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Suspension Oral Suspension Oral 400 mg Tablet, film coated Oral Capsule Oral Syrup Oral 1.8 MG/ML Suspension Oral 0.4 g Tablet Oral Suspension Oral 708.000 mg Capsule Oral 35.000 mg Suspension Oral 708 MG/100ML Solution / drops Oral Syrup Oral Tablet, chewable Oral Tablet, coated Syrup Oral 354.000 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source boiling point (°C) 178-180 Merck Index 2358. - Predicted Properties
Property Value Source Water Solubility 0.000765 mg/mL ALOGPS logP 5.08 ALOGPS logP 5.11 Chemaxon logS -5.6 ALOGPS pKa (Strongest Basic) 8.82 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 12.47 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 96.87 m3·mol-1 Chemaxon Polarizability 37.23 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at June 17, 2014 17:02 / Updated at March 03, 2023 17:48