Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Batroxobin
- DrugBank Accession Number
- DB09005
- Background
Batroxobin is a defibrinogenating hemostatic agent derived from the venom of a pit viper, Bothrops atrox moojeni. In addition to batroxobin, the venom of Bothrops atrox has a composition of 10.2% neutral carbohydrate. Batroxobin is a serine protease, which cleaves the 16 Arginine - 17 Glycine bond in fibrinogen. The MW of batroxobin is approximately 43,000 g/mol-1, and it contains 231 amino acids.
Batroxobin is inactivated by alpha2-macroglobulin, but not anti-thrombin compounds. Batroxobin will also bind fibrinogen in a manner different than thrombin and with a higher affinity. Once bound to fibrin, it will cause fibrin accretion(clot formation) to a degree 18 folds greater than thrombin.
Currently use is experimental but trials have been conducted which support certain clinical applications. Recombinant Batroxobin in relatively affordable and could be accessed by mass production.
- Type
- Biotech
- Groups
- Experimental
- Biologic Classification
- Protein Based Therapies
Blood factors - Protein Chemical Formula
- Not Available
- Protein Average Weight
- Not Available
- Sequences
- Not Available
- Synonyms
- Batroxobin
- Batroxobina
- Batroxobine
- Batroxobinum
- Bothrops atrox blood-coagulation factor X activator
- External IDs
- DF 521
- DF-521
Pharmacology
- Indication
No approved indications. Batroxobin is a defibrongenating agent which has been observed to reduce fibrinogen levels and thus reduce clot risk when used intravenously.
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Insensitive to thrombin inhibitors and capable of clotting platelet rich plasma without affecting platelet function.
- Mechanism of action
Batroxobin is a thrombin like serine protease enzyme that will cleave fibrinogen. Cleavage at the16 Arginine - 17 Glycine bond in the A alpha chain of fibrinogen releases fibrinopeptide A and forms a fibrin I monomer that will spontaneously aggregate into a clot. The reduction of plasma fibrinogen by formation of fibrin microclots that are easily cleared by the reticuloendothelial system can decrease high blood viscosity which contributes to the formation of thromboemboli.
In addition, batroxobin is reported to induce fibrinolysis by inducing the endothelial release of tissue plasminogen activator (tPA) from vascular endothelial cells. This effect may potentially be dose dependant.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- International/Other Brands
- Ba Qu Ting (Belda Gaoke Huatal Pharmaceutical, China) / Batraxobin (Tobishi Pharmaceutical, China) / Botroclot (Juggat, India) / Botropase (Han Lim, South Korea) / Defibrase (Tobishi Pharmaceutical, Japan) / Reptilase / Su Le Juan (Zhaoke Pharmaceutical, China) / Su Ling (Kangchen Pharmaceutical, China)
Categories
- ATC Codes
- B02BX03 — Batroxobin
- Drug Categories
- Biological Factors
- Blood and Blood Forming Organs
- Cardiovascular Agents
- Coagulants
- Complex Mixtures
- Crotalid Venoms
- Endopeptidases
- Enzymes
- Enzymes and Coenzymes
- Fibrin Modulating Agents
- Hematologic Agents
- Hemostatics
- Hydrolases
- Peptide Hydrolases
- Serine Endopeptidases
- Serine Proteases
- Snake Venoms
- Toxins, Biological
- Venombin A
- Venoms
- Viper Venoms
- Chemical TaxonomyProvided by Classyfire
- Description
- Not Available
- Kingdom
- Organic Compounds
- Super Class
- Organic Acids
- Class
- Carboxylic Acids and Derivatives
- Sub Class
- Amino Acids, Peptides, and Analogues
- Direct Parent
- Peptides
- Alternative Parents
- Not Available
- Substituents
- Not Available
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 47RYF40GA9
- CAS number
- 9039-61-6
References
- General References
- Mannucci PM, Mari D: [Fibrinolytic and defibrinogenation therapy]. Ric Clin Lab. 1983;13 Suppl 3:245-55. [Article]
- Vu TT, Stafford AR, Leslie BA, Kim PY, Fredenburgh JC, Weitz JI: Batroxobin binds fibrin with higher affinity and promotes clot expansion to a greater extent than thrombin. J Biol Chem. 2013 Jun 7;288(23):16862-71. doi: 10.1074/jbc.M113.464750. Epub 2013 Apr 23. [Article]
- Wang J, Zhu YQ, Li MH, Zhao JG, Tan HQ, Wang JB, Liu F, Cheng YS: Batroxobin plus aspirin reduces restenosis after angioplasty for arterial occlusive disease in diabetic patients with lower-limb ischemia. J Vasc Interv Radiol. 2011 Jul;22(7):987-94. doi: 10.1016/j.jvir.2011.03.015. Epub 2011 May 14. [Article]
- Xu G, Liu X, Zhu W, Yin Q, Zhang R, Fan X: Feasibility of treating hyperfibrinogenemia with intermittently administered batroxobin in patients with ischemic stroke/transient ischemic attack for secondary prevention. Blood Coagul Fibrinolysis. 2007 Mar;18(2):193-7. [Article]
- You KE, Koo MA, Lee DH, Kwon BJ, Lee MH, Hyon SH, Seomun Y, Kim JT, Park JC: The effective control of a bleeding injury using a medical adhesive containing batroxobin. Biomed Mater. 2014 Apr;9(2):025002. doi: 10.1088/1748-6041/9/2/025002. Epub 2014 Jan 31. [Article]
- External Links
- Wikipedia
- Batroxobin
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data4 Unknown Status Treatment Batroxobin / Cerebrovascular venous and sinus thrombosis 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
Drug created at June 17, 2014 22:15 / Updated at February 21, 2021 18:52