Coagulation factor X

BE0000216ProteinHumansF10

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (PubMed:22409427, PubMed:39880037). It is acted on by 87 drugs in DrugBank.

Gene name
F10
UniProtKB entry
P00742Swiss-Prot
Cellular location
Secreted
Residues / weight
488 residues · 54,731 Da
Also known as
3.4.21.6 · Stuart factor · Stuart-Prower factor

Resolves to

Protein
UniProtP00742UniProt nameFA10_HUMAN
Gene
HGNCHGNC:3528NCBI Gene2159GenBank182841GeneCardsF10
Pharmacology
IUPHAR/GtoPdb2359KEGGhsa:2159
Structure
PDB1C5MPDB1EZQPDB1F0R
Drugs

What you can answer from here — as of September 07, 2019

87DrugsApproved to experimental, with action, bond type and pharmacological action
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12Clinical trialsTrials of drugs acting on it, by phase and status
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2GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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249+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Coagulation factor X, how selective are they, and which programs against it are still in active trials?

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