Florbetaben F-18 is a radiopharmaceutical diagnostic agent used during Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients to diagnose the causes of cognitive impairment. A medication used during diagnostic tests to look for signs of cognitive impairment due to any medical conditions, such as Alzheimer’s Disease.
- Mechanism
- Curator reviewed · 4 references
Beta (β)-amyloid plaques that accumulate in the brain can lead to disrupted neuronal cell function and cell death. While the presence of β-amyloid plaques alone is insufficient to diagnose Alzheimer's disease (AD), cognitive impairment and the presence of β-amyloid plaques is strongly indicative of AD.
Florbetaben F-18 binds to amyloid beta plaques in the brain and the F-18 isotope produces a positron signal that is detected by a PET scanner. 3H-florbetaben in vitro binding experiments revealed two binding sites (Kd of 16 nM and 135 nM) in frontal cortex homogenates from patients with AD. Binding of florbetaben F-18 to amyloid beta plaques in postmortem brain sections from patients with AD using autoradiography correlated with both immunohistochemical and Bielschowsky silver stains. Florbetaben F-18 did not bind to tau or α-synuclein in tissue from patients with AD. Neither florbetaben F-18 nor non-radioactive florbetaben F 19 bound to AT8 positive tau deposited in brain tissue from patients with frontotemporal dementia (FTD), using autoradiography and immunohistochemistry, respectively.
- Primary indication
- Florbetaben F-18 is indicated for positron emission tomography (PET) of the brain to estimate amyloid beta neuritic plaque density in adults with cognitive impairment for: Evaluation of Alzheimer’s disease (AD) and other causes of cognitive...Curator reviewed · 3 structured indications
- Formula / weight
- C21H26FNO3 · 358.444 g/mol (avg)
- First approval
- United States, 2014 · European Union, 2016
- Also known as
- 4-((1E)-2-(4-(2-(2-(2-((SUP 18(F))FLUOROETHOXY)ETHOXY)ETHOXY)PHENYL)ETH-1-EN-1-YL)-N-METHYLANILINE · 4-[(E)-2-(4-{2-[2-(2-[18F] fluoroethoxy)ethoxy]ethoxy}phenyl)vinyl]-Nmethylaniline · Florbetaben (18F) · florbetaben (¹⁸F) · florbetaben F18
- Code names
- AV-1 · BAY-94-9172 · ZK-6013443
- Brand names
Resolves to
NCWZOASIUQVOFA-FWZJPQCDSA-NSMILESCNC1=CC=C(\C=C\C2=CC=C(OCCOCCOCC[18F])C=C2)C=C1What you can answer from here — as of September 13, 2026
Which drugs share a target with Florbetaben F-18, and which of those have an active Phase 3 trial?
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