Amyloid-beta precursor protein

BE0003392ProteinHumansAPP

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. It is acted on by 51 drugs in DrugBank.

Gene name
APP
UniProtKB entry
P05067Swiss-Prot
Cellular location
Cell membrane
Residues / weight
770 residues · 86,943 Da
Also known as
A4 · ABPP · AD1 · Alzheimer disease amyloid A4 protein homolog · Alzheimer disease amyloid protein

Resolves to

Protein
UniProtP05067UniProt nameA4_HUMAN
Gene
HGNCHGNC:620NCBI Gene351GeneCardsAPP
Pharmacology
KEGGhsa:351
Structure
PDB12GBPDB1AAPPDB1AMB
Drugs

What you can answer from here — as of September 03, 2024

51DrugsApproved to experimental, with action, bond type and pharmacological action
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67GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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243+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Amyloid-beta precursor protein, how selective are they, and which programs against it are still in active trials?

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