Selenic acid
Identification
- Summary
Selenic acid is an ingredient found in a variety of supplements and vitamins.
- Generic Name
- Selenic acid
- DrugBank Accession Number
- DB11068
- Background
Selenic acid is an organic compound with the chemical formula H2SeO4. It may be found in over-the-counter daily dietary supplements as a source of Selenium, an essential trace mineral for human health.
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 144.97
Monoisotopic: 145.91183038 - Chemical Formula
- H2O4Se
- Synonyms
- Not Available
- External IDs
- UN-1905
- UN1905
Pharmacology
- Indication
Indicated for use as a nutritional supplement.
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- Contraindications & Blackbox Warnings
- Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.
- Pharmacodynamics
Selenium is an essential trace mineral that plays a critical role in antioxidant actions, anti-inflammatory effects, immune function, and the production of active thyroid hormone 1.
- Mechanism of action
Selenium is a constituent of selenoproteins thus has structural and enzymatic roles. It acts as an antioxidant via the actions of selenoproteins for protection against oxidative stress, and acts as a catayst for the production of active thyroid hormone []. It may also play a role in sperm motility 2.
- Absorption
Following single oral administration of sodium selenate concentrations ranging from 1 mg Se/kg to 4 mg Se/kg in lambs, the peak plasma concentrations ranged from 0.79 mg Se/L to 2.54 mg Se/L 3. The time to reach peak plasma concentrations ranged from 7 to 12 hours 3.
- Volume of distribution
No pharmacokinetic data available.
- Protein binding
No pharmacokinetic data available.
- Metabolism
No pharmacokinetic data available.
- Route of elimination
Not Available
- Half-life
Following single oral administration of 1 mg Se/kg of sodium selenate in lambs, the elimination half life was 313 hours. The elimination half life was 142 hours following a single oral dosing of 4 mg Se/kg as sodium selenate 3.
- Clearance
No pharmacokinetic data available.
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Injectable selenium is more acutely toxic than oral administration, with an intramuscular LD50 of 0.5 mg/kg BW in lambs 3.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareEltrombopag The bioavailability of Selenic acid can be decreased when combined with Eltrombopag. Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Sodium selenate 5DQP25600A 13410-01-0 MHQOTKLEMKRJIR-UHFFFAOYSA-L - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Balance Ace - Cap Sodium selenate (15 mcg) + Ascorbic acid (250 mg) + Beta carotene (10000 unit) + Cupric oxide (1 mg) + DL-alpha tocopheryl acetate (200 unit) + Manganese sulfate (1.5 mg) + Zinc oxide (7.5 mg) Capsule Oral Pharmavite 1996-09-06 2002-07-25 Canada Beta A With Vitamins C and E Plus Selenium Sodium selenate (25 mcg) + Ascorbic acid (250 mg) + Beta carotene (10000 unit) + Vitamin E (200 unit) Capsule Oral Vita Health Products Inc 1996-10-11 2002-07-31 Canada Cell-wise Natural Source Sodium selenate (25 mcg / tab) + Ascorbic acid (200 mg / tab) + Beta carotene (5000 unit / tab) + Calcium (82.5 mg / tab) + Cupric oxide (1 mg / tab) + Manganese (1.5 mg / tab) + Vitamin E (200 unit / tab) + Zinc (7.5 mg / tab) Tablet Oral Melaleuca, Inc. 1998-05-26 2005-06-28 Canada High Potency Multivitamins & Minerals Caplets Sodium selenate (50 mcg) + Ascorbic acid (100 mg) + Beta carotene (2500 unit) + Biotin (45 mcg) + Calcium phosphate, dibasic (125 mg) + Calcium Phosphate (175 mg) + Cholecalciferol (400 unit) + Chromic chloride (50 mcg) + Cupric sulfate (2 mg) + Cyanocobalamin (9 mcg) + Ferrous fumarate (10 mg) + Folic acid (0.4 mg) + Magnesium oxide (100 mg) + Manganese sulfate (5 mg) + Nickel sulfate (5 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Potassium Iodide (0.15 mg) + Potassium chloride (50 mg) + Potassium chloride (55 mg) + Pyridoxine hydrochloride (4 mg) + Riboflavin (3.4 mg) + Silicon dioxide (0.01 mg) + Sodium metavanadate (10 mcg) + Sodium molybdate (50 mcg) + Stannous chloride (0.01 mg) + Thiamine mononitrate (3 mg) + Vitamin A acetate (3500 unit) + Zinc citrate (20 mg) + alpha-Tocopherol acetate (50 unit) Tablet Oral Ashbury Research Corporation Not applicable Not applicable Canada K.L. Vitamin-mineral Sodium selenate (24.5 mcg / 45 g) + Ascorbic acid (21 mg / 45 g) + Biotin (105 mcg / 45 g) + Calcium (250 mg / 45 g) + Calcium Phosphate (150 mg / 45 g) + Cholecalciferol (140 unit / 45 g) + Chromium (42 mcg / 45 g) + Copper (0.7 mg / 45 g) + Cyanocobalamin (2.1 mcg / 45 g) + Ferrous sulfate (6.3 mg / 45 g) + Folic acid (0.140 mg / 45 g) + Magnesium (80 mg / 45 g) + Manganese (0.7 mg / 45 g) + Nicotinamide (7 mg / 45 g) + Calcium pantothenate (3.5 mg / 45 g) + Potassium Iodide (0.0525 mg / 45 g) + Pyridoxine hydrochloride (0.7 mg / 45 g) + Riboflavin (0.6 mg / 45 g) + Sodium molybdate (25 mcg / 45 g) + Thiamine (0.5 mg / 45 g) + Vitamin A palmitate (1750 unit / 45 g) + Zinc (5.25 mg / 45 g) + alpha-Tocopherol acetate (10.5 unit / 45 g) Powder Oral Abundance Naturally Ltd Not applicable Not applicable Canada Materna Sodium selenate (25 mcg) + Ascorbic acid (100 mg) + Beta carotene (1500 unit) + Biotin (30 mcg) + Calcium carbonate (250 mg) + Cholecalciferol (250 unit) + Chromic chloride (25 mcg) + Cupric oxide (2 mg) + Cyanocobalamin (12 mcg) + Ferrous fumarate (27 mg) + Folic acid (1 mg) + Magnesium oxide (50 mg) + Manganese sulfate (5 mg) + Nicotinamide (20 mg) + Calcium pantothenate (10 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (10 mg) + Riboflavin (3.4 mg) + Sodium molybdate (25 mcg) + Thiamine mononitrate (3 mg) + Vitamin A acetate (1500 unit) + Zinc oxide (25 mg) + alpha-Tocopherol acetate (30 unit) Tablet Oral Wyeth Ltd. 2004-05-17 2006-07-24 Canada Ocuvite Tab Sodium selenate (40 mcg) + Ascorbic acid (60 mg) + Beta carotene (5000 unit) + Cupric oxide (2 mg) + DL-alpha tocopheryl acetate (30 unit) + Zinc oxide (40 mg) Tablet Oral Bausch & Lomb Inc 1992-12-31 2002-07-29 Canada One Daily Vitamin and Mineral Dietary Supplement Sodium selenate (10 mcg) + Ascorbic acid (60 mg) + Beta carotene (5000 unit) + Biotin (30 mcg) + Calcium (130 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (6 mcg) + Ferrous fumarate (18 mg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Manganese (2.5 mg) + Nicotinamide (20 mg) + Pantothenic acid (10 mg) + Potassium (37.5 mg) + Potassium Iodide (0.15 mg) + Potassium chloride (34 mg) + Pyridoxine hydrochloride (2 mg) + Riboflavin (1.7 mg) + Sodium molybdate (10 mcg) + Thiamine hydrochloride (1.5 mg) + Vitamin A (1500 unit) + Zinc (15 mg) + alpha-Tocopherol acetate (30 unit) Tablet Oral Garden State Nutritionals 1998-09-25 2000-06-07 Canada One Tablet Daily Mens Formula Sodium selenate (87.5 mcg) + Ascorbic acid (90 mg) + Beta carotene (1000 unit) + Chromic chloride (150 mcg) + Cupric oxide (2 mg) + Cyanocobalamin (9 mcg) + Folic acid (0.4 mg) + Magnesium oxide (100 mg) + Manganese sulfate (3.5 mg) + Nicotinamide (20 mg) + Calcium pantothenate (10 mg) + Potassium Iodide (0.15 mg) + Potassium chloride (37.5 mg) + Potassium chloride (34 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (2.55 mg) + Sodium molybdate (42 mcg) + Thiamine mononitrate (2.25 mg) + Vitamin A acetate (4000 unit) + Vitamin D (400 unit) + Vitamin E (45 unit) + Zinc oxide (15 mg) Tablet Oral Vita Health Products Inc 2003-05-16 2008-08-05 Canada One-A-day Advance Men's Sodium selenate (87.5 mcg) + Ascorbic acid (90 mg) + Beta carotene (1000 unit) + Chromic chloride (150 mcg) + Cupric sulfate (2 mg) + Cyanocobalamin (9 mcg) + Folic acid (0.4 mg) + Magnesium hydroxide (100 mg) + Manganese sulfate (3.3 mg) + Niacin (20 mg) + Calcium pantothenate (10 mg) + Potassium Iodide (0.15 mg) + Potassium chloride (34 mg) + Potassium chloride (37.5 mg) + Pyridoxine (3 mg) + Riboflavin (2.55 mg) + Sodium molybdate (41.7 mcg) + Thiamine mononitrate (2.25 mg) + Vitamin A acetate (4000 unit) + Vitamin D (400 unit) + Zinc sulfate (15 mg) + alpha-Tocopherol acetate (45 unit) Tablet Oral Bayer Inc Consumer Care 2000-08-01 2002-02-06 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Cavan Heme OB Sodium selenate (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Iron (28 mg/1) + Niacin (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (175 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (15 mg/1) + alpha-Tocopherol succinate (10 [iU]/1) Tablet Oral Seton Pharmaceuticals 2010-08-03 2012-06-10 US Duet DHA Balanced Sodium selenate (65 ug/1) + Ascorbic acid (120 mg/1) + Beta carotene (2800 [iU]/1) + Calcium carbonate (215 mg/1) + Cholecalciferol (640 [iU]/1) + Choline (55 mg/1) + Cupric oxide (1.8 mg/1) + Cyanocobalamin (12 ug/1) + D-alpha-Tocopherol acetate (15 mg/1) + Folic acid (1 mg/1) + Iodine (210 ug/1) + Iron (25 mg/1) + Magnesium (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (267 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (2 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (25 mg/1) Capsule, gelatin coated; Kit; Tablet Oral Eckson Labs, LLC 2012-10-30 Not applicable US HemeNatal OB Sodium selenate (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron sucrose (28 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1) Tablet Oral Wh Nutritionals, Llc 2012-03-08 2018-06-30 US HemeNatal OB plus DHA Sodium selenate (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Doconexent (200 mg/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron sucrose (28 mg/1) + Nicotinamide (17 mg/1) + Osbond acid (2.5 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Linolenic acid (0.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1) Kit Oral Wh Nutritionals, Llc 2012-03-08 2019-04-30 US Paire OB Plus DHA Sodium selenate (65 ug/1) + Biotin (30 ug/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + D-alpha-Tocopherol acetate (10 [iU]/1) + Doconexent (200 mg/1) + Ferrous asparto glycinate (6 mg/1) + Folic acid (1 mg/1) + Iron (22 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (175 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (15 mg/1) Kit Oral Centrix Pharmaceutical 2010-10-13 2015-07-31 US PreferaOB Sodium selenate (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron sucrose (28 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1) Tablet, coated Oral MEDA Pharmaceuticals 2015-04-28 2018-08-31 US PreferaOB plus DHA Sodium selenate (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron sucrose (28 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Schizochytrium DHA oil (200 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1) Capsule, liquid filled; Kit; Tablet, coated Oral MEDA Pharmaceuticals 2015-02-01 2018-08-31 US Vp-heme Ob Sodium selenate (65 mg/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Copper gluconate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron sucrose (28 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1) Tablet, film coated Oral Virtus Pharmaceuticals 2013-10-14 2016-05-31 US Vp-heme Ob DHA Sodium selenate (65 mg/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.80 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron sucrose (28 mg/1) + Niacin (17 mg/1) + Omega-3 fatty acids (203 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1) Kit Oral Virtus Pharmaceuticals 2013-12-01 2016-02-05 US
Categories
- ATC Codes
- A12CE01 — Sodium selenate
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- HV0Y51NC4J
- CAS number
- 7783-08-6
- InChI Key
- QYHFIVBSNOWOCQ-UHFFFAOYSA-N
- InChI
- InChI=1S/H2O4Se/c1-5(2,3)4/h(H2,1,2,3,4)
- IUPAC Name
- selenic acid
- SMILES
- O[Se](O)(=O)=O
References
- General References
- Rayman MP: Selenium and human health. Lancet. 2012 Mar 31;379(9822):1256-68. doi: 10.1016/S0140-6736(11)61452-9. Epub 2012 Feb 29. [Article]
- Rayman MP: The importance of selenium to human health. Lancet. 2000 Jul 15;356(9225):233-41. doi: 10.1016/S0140-6736(00)02490-9. [Article]
- Davis TZ, Stegelmeier BL, Welch KD, Pfister JA, Panter KE, Hall JO: Comparative oral dose toxicokinetics of selenium compounds commonly found in selenium accumulator plants. J Anim Sci. 2013 Sep;91(9):4501-9. doi: 10.2527/jas.2012-6101. Epub 2013 Jul 3. [Article]
- External Links
- Human Metabolome Database
- HMDB0062761
- KEGG Compound
- C05697
- PubChem Compound
- 1089
- PubChem Substance
- 347827883
- ChemSpider
- 1058
- BindingDB
- 50147596
- ChEBI
- 18170
- ChEMBL
- CHEMBL2097002
- PDBe Ligand
- SE4
- Wikipedia
- Selenic_acid
- MSDS
- Download (48 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Withdrawn Treatment Thyroid Associated Ophthalmopathy 1 1, 2 Completed Prevention Deficiency, Vitamin D / Prophylaxis of preeclampsia 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral Tablet Oral Capsule, gelatin coated; kit; tablet Oral Powder Oral Capsule, liquid filled; kit; tablet Oral Capsule, liquid filled; kit; tablet, film coated Oral Kit Oral Tablet, coated Oral Capsule, liquid filled; kit; tablet, coated Oral Tablet, film coated Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 70 MSDS boiling point (°C) Decomposes MSDS water solubility Soluble MSDS - Predicted Properties
Property Value Source logP -1.6 Chemaxon pKa (Strongest Acidic) -3.8 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 74.6 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 21.13 m3·mol-1 Chemaxon Polarizability 6.65 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-0900000000-ce27aa482e96edc8d2c3 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-0900000000-a8b1c495851747f01491 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-1900000000-5aea84da45d6f46389b1 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-0900000000-b27e0c5103000de8e548 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-1900000000-5e615f49bdaf4a1a74a7 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-0900000000-30844102eaffa8a1b188
Drug created at December 03, 2015 16:51 / Updated at September 28, 2021 21:54