Identification
- Summary
Selenic acid is an ingredient found in a variety of supplements and vitamins.
- Generic Name
- Selenic acid
- DrugBank Accession Number
- DB11068
- Background
Selenic acid is an organic compound with the chemical formula H2SeO4. It may be found in over-the-counter daily dietary supplements as a source of Selenium, an essential trace mineral for human health.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Selenic acid (DB11068)
- Weight
- Average: 144.97
Monoisotopic: 145.91183038 - Chemical Formula
- H2O4Se
- Synonyms
- Not Available
- External IDs
- UN-1905
- UN1905
Pharmacology
- Indication
Indicated for use as a nutritional supplement.
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- Contraindications & Blackbox Warnings
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Selenium is an essential trace mineral that plays a critical role in antioxidant actions, anti-inflammatory effects, immune function, and the production of active thyroid hormone 1.
- Mechanism of action
Selenium is a constituent of selenoproteins thus has structural and enzymatic roles. It acts as an antioxidant via the actions of selenoproteins for protection against oxidative stress, and acts as a catayst for the production of active thyroid hormone []. It may also play a role in sperm motility 2.
- Absorption
Following single oral administration of sodium selenate concentrations ranging from 1 mg Se/kg to 4 mg Se/kg in lambs, the peak plasma concentrations ranged from 0.79 mg Se/L to 2.54 mg Se/L 3. The time to reach peak plasma concentrations ranged from 7 to 12 hours 3.
- Volume of distribution
No pharmacokinetic data available.
- Protein binding
No pharmacokinetic data available.
- Metabolism
No pharmacokinetic data available.
- Route of elimination
Not Available
- Half-life
Following single oral administration of 1 mg Se/kg of sodium selenate in lambs, the elimination half life was 313 hours. The elimination half life was 142 hours following a single oral dosing of 4 mg Se/kg as sodium selenate 3.
- Clearance
No pharmacokinetic data available.
- Adverse Effects
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Injectable selenium is more acutely toxic than oral administration, with an intramuscular LD50 of 0.5 mg/kg BW in lambs 3.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareEltrombopag The bioavailability of Selenic acid can be decreased when combined with Eltrombopag. - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Sodium selenate 5DQP25600A 13410-01-0 MHQOTKLEMKRJIR-UHFFFAOYSA-L - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Balance Ace - Cap Sodium selenate (15 mcg) + Ascorbic acid (250 mg) + Beta carotene (10000 unit) + Cupric oxide (1 mg) + DL-alpha tocopheryl acetate (200 unit) + Manganese sulfate (1.5 mg) + Zinc oxide (7.5 mg) Capsule Oral Pharmavite 1996-09-06 2002-07-25 Canada 
Beta A With Vitamins C and E Plus Selenium Sodium selenate (25 mcg) + Ascorbic acid (250 mg) + Beta carotene (10000 unit) + Vitamin E (200 unit) Capsule Oral Vita Health Products Inc 1996-10-11 2002-07-31 Canada Cell-wise Natural Source Sodium selenate (25 mcg / tab) + Ascorbic acid (200 mg / tab) + Beta carotene (5000 unit / tab) + Calcium (82.5 mg / tab) + Cupric oxide (1 mg / tab) + Manganese (1.5 mg / tab) + Vitamin E (200 unit / tab) + Zinc (7.5 mg / tab) Tablet Oral Melaleuca, Inc. 1998-05-26 2005-06-28 Canada High Potency Multivitamins & Minerals Caplets Sodium selenate (50 mcg) + Ascorbic acid (100 mg) + Beta carotene (2500 unit) + Biotin (45 mcg) + Calcium phosphate, dibasic (125 mg) + Calcium Phosphate (175 mg) + Cholecalciferol (400 unit) + Chromic chloride (50 mcg) + Cupric sulfate (2 mg) + Cyanocobalamin (9 mcg) + Ferrous fumarate (10 mg) + Folic acid (0.4 mg) + Magnesium oxide (100 mg) + Manganese sulfate (5 mg) + Nickel sulfate (5 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Potassium Iodide (0.15 mg) + Potassium chloride (50 mg) + Potassium chloride (55 mg) + Pyridoxine hydrochloride (4 mg) + Riboflavin (3.4 mg) + Silicon dioxide (0.01 mg) + Sodium metavanadate (10 mcg) + Sodium molybdate (50 mcg) + Stannous chloride (0.01 mg) + Thiamine mononitrate (3 mg) + Vitamin A acetate (3500 unit) + Zinc citrate (20 mg) + alpha-Tocopherol acetate (50 unit) Tablet Oral Ashbury Research Corporation Not applicable Not applicable Canada K.L. Vitamin-mineral Sodium selenate (24.5 mcg / 45 g) + Ascorbic acid (21 mg / 45 g) + Biotin (105 mcg / 45 g) + Calcium (250 mg / 45 g) + Calcium Phosphate (150 mg / 45 g) + Cholecalciferol (140 unit / 45 g) + Chromium (42 mcg / 45 g) + Copper (0.7 mg / 45 g) + Cyanocobalamin (2.1 mcg / 45 g) + Ferrous sulfate (6.3 mg / 45 g) + Folic acid (0.140 mg / 45 g) + Magnesium (80 mg / 45 g) + Manganese (0.7 mg / 45 g) + Nicotinamide (7 mg / 45 g) + Calcium pantothenate (3.5 mg / 45 g) + Potassium Iodide (0.0525 mg / 45 g) + Pyridoxine hydrochloride (0.7 mg / 45 g) + Riboflavin (0.6 mg / 45 g) + Sodium molybdate (25 mcg / 45 g) + Thiamine (0.5 mg / 45 g) + Vitamin A palmitate (1750 unit / 45 g) + Zinc (5.25 mg / 45 g) + alpha-Tocopherol acetate (10.5 unit / 45 g) Powder Oral Abundance Naturally Ltd Not applicable Not applicable Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Cavan Heme OB Sodium selenate (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Iron (28 mg/1) + Niacin (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (175 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (15 mg/1) + alpha-Tocopherol succinate (10 [iU]/1) Tablet Oral Seton Pharmaceuticals 2010-08-03 2012-06-10 US 
Duet DHA Balanced Sodium selenate (65 ug/1) + Ascorbic acid (120 mg/1) + Beta carotene (2800 [iU]/1) + Calcium carbonate (215 mg/1) + Cholecalciferol (640 [iU]/1) + Choline (55 mg/1) + Cupric oxide (1.8 mg/1) + Cyanocobalamin (12 ug/1) + D-alpha-Tocopherol acetate (15 mg/1) + Folic acid (1 mg/1) + Iodine (210 ug/1) + Iron (25 mg/1) + Magnesium (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (267 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (2 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (25 mg/1) Capsule, gelatin coated; Kit; Tablet Oral Eckson Labs, LLC 2012-10-30 Not applicable US HemeNatal OB Sodium selenate (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron sucrose (28 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1) Tablet Oral Wh Nutritionals, Llc 2012-03-08 2018-06-30 US HemeNatal OB plus DHA Sodium selenate (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Doconexent (200 mg/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron sucrose (28 mg/1) + Nicotinamide (17 mg/1) + Osbond acid (2.5 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Linolenic acid (0.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1) Kit Oral Wh Nutritionals, Llc 2012-03-08 2019-04-30 US Paire OB Plus DHA Sodium selenate (65 ug/1) + Biotin (30 ug/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + D-alpha-Tocopherol acetate (10 [iU]/1) + Doconexent (200 mg/1) + Ferrous asparto glycinate (6 mg/1) + Folic acid (1 mg/1) + Iron (22 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (175 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (15 mg/1) Kit Oral Centrix Pharmaceutical 2010-10-13 2015-07-31 US
Categories
- ATC Codes
- A12CE01 — Sodium selenate
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- HV0Y51NC4J
- CAS number
- 7783-08-6
- InChI Key
- QYHFIVBSNOWOCQ-UHFFFAOYSA-N
- InChI
- InChI=1S/H2O4Se/c1-5(2,3)4/h(H2,1,2,3,4)
- IUPAC Name
- selenic acid
- SMILES
- O[Se](O)(=O)=O
References
- General References
- Rayman MP: Selenium and human health. Lancet. 2012 Mar 31;379(9822):1256-68. doi: 10.1016/S0140-6736(11)61452-9. Epub 2012 Feb 29. [Article]
- Rayman MP: The importance of selenium to human health. Lancet. 2000 Jul 15;356(9225):233-41. doi: 10.1016/S0140-6736(00)02490-9. [Article]
- Davis TZ, Stegelmeier BL, Welch KD, Pfister JA, Panter KE, Hall JO: Comparative oral dose toxicokinetics of selenium compounds commonly found in selenium accumulator plants. J Anim Sci. 2013 Sep;91(9):4501-9. doi: 10.2527/jas.2012-6101. Epub 2013 Jul 3. [Article]
- External Links
- Human Metabolome Database
- HMDB0062761
- KEGG Compound
- C05697
- PubChem Compound
- 1089
- PubChem Substance
- 347827883
- ChemSpider
- 1058
- BindingDB
- 50147596
- ChEBI
- 18170
- ChEMBL
- CHEMBL2097002
- PDBe Ligand
- SE4
- Wikipedia
- Selenic_acid
- MSDS
- Download (48 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Withdrawn Treatment Thyroid Associated Ophthalmopathy 1 1, 2 Completed Prevention Deficiency, Vitamin D / Pre-Eclampsia 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral Tablet Oral Capsule, gelatin coated; kit; tablet Oral Powder Oral Capsule, liquid filled; kit; tablet Oral Capsule, liquid filled; kit; tablet, film coated Oral Kit Oral Tablet, coated Oral Capsule, liquid filled; kit; tablet, coated Oral Tablet, film coated Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 70 MSDS boiling point (°C) Decomposes MSDS water solubility Soluble MSDS - Predicted Properties
Property Value Source logP -1.6 Chemaxon pKa (Strongest Acidic) -3.8 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 74.6 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 21.13 m3·mol-1 Chemaxon Polarizability 6.65 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 119.51314 predictedDeepCCS 1.0 (2019) [M+H]+ 122.311646 predictedDeepCCS 1.0 (2019) [M+Na]+ 130.43404 predictedDeepCCS 1.0 (2019)
Drug created at December 03, 2015 16:51 / Updated at September 28, 2021 21:54