Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

BE0002326ProteinHumansPPP2CA

Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (PubMed:10801873, PubMed:12473674, PubMed:17245430, PubMed:22613722, PubMed:33243860, PubMed:34004147, PubMed:9920888, PubMed:41986709). It is acted on by 7 drugs in DrugBank.

Gene name
PPP2CA
UniProtKB entry
P67775Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
309 residues · 35,594 Da
Also known as
3.1.3.16 · PP2A-alpha · Replication protein C · RP-C

Resolves to

Protein
UniProtP67775UniProt namePP2AA_HUMAN
Gene
HGNCHGNC:9299NCBI Gene5515GenBank36120GeneCardsPPP2CA
Pharmacology
IUPHAR/GtoPdb3263KEGGhsa:5515
Structure
PDB2IAEPDB2IE3PDB2IE4
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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40+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, how selective are they, and which programs against it are still in active trials?

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