Pyrethrum extract

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Pyrethrum extract
Accession Number
DB11087
Description

Pyrethrum is the crude extract form obtained from flowers of the plant Chrysanthemum cinerariifolium. Pyrethrin refers to a more refined extract of pyrethrum. While pyrethrum extract is composed of 6 esters, both organic compounds mediate insecticidal activities. Pyrethrum-containing mixtures are used as a common insecticide to control specific pest species. Pyrethrum extract is also used used to treat head, body, and pubic lice infections. The active compound is absorbed by the lice and destroys them by acting on their nervous systems but is thought to exert minimal effect on humans.

Type
Biotech
Groups
Approved
Biologic Classification
Allergenics
Allergen Extract
Synonyms
  • Allergenic extract, pyrethrum
  • Chrysanthemum cinerariifolium pyrethrins extract
  • Pyrethrins
  • Pyrethrins and pyrethroids
  • Pyrethrins component of rid mousse
  • Pyrethrum
  • Pyrethrum extract
  • Pyrethrum oleo resin
  • Pyrethrum oleoresin
  • Rid mousse component pyrethrins
  • Tanacetum cinerariifolium pyrethrins extract

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
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Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UNuclear receptor subfamily 1 group I member 2Not AvailableHumans
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
PyrethrumSolution0.05 g/1mLIntradermal; Percutaneous; SubcutaneousGreer Laboratories, Inc.1981-09-15Not applicableUS flag
PyrethrumSolution20000 [PNU]/1mLIntradermal; Percutaneous; SubcutaneousGreer Laboratories, Inc.1981-09-15Not applicableUS flag
PyrethrumSolution0.001 g/1mLIntradermal; Percutaneous; SubcutaneousGreer Laboratories, Inc.1981-09-15Not applicableUS flag
PyrethrumSolution0.1 g/1mLIntradermal; Percutaneous; SubcutaneousGreer Laboratories, Inc.1981-09-15Not applicableUS flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Best Choice Lice KillingPyrethrum extract (0.33 g/100mL) + Piperonyl butoxide (4 g/100mL)ShampooTopicalValue Merchandisers2010-10-28Not applicableUS flag
Best Choice Lice treatmentPyrethrum extract (3.3 mg/1mL) + Piperonyl butoxide (40 mg/1mL)KitTopicalValue Merchandisers2010-10-28Not applicableUS flag
Care One Lice KillingPyrethrum extract (0.33 g/100mL) + Piperonyl butoxide (4 g/100mL)ShampooTopicalAmerican Sales Company2007-08-29Not applicableUS flag
Careone Complete Kit LicePyrethrum extract (.33 g/100mL) + Piperonyl butoxide (4 g/100mL)KitTopicalAmerican Sales Company2019-01-26Not applicableUS flag
Careone LicePyrethrum extract (0.33 g/100mL) + Piperonyl butoxide (4 g/100mL)TopicalAmerican Sales Company2007-09-262013-10-28US flag
CareOne Lice SolutionPyrethrum extract (0.33 g/100mL) + Piperonyl butoxide (4 g/100mL)KitTopicalAmerican Sales Company2016-04-29Not applicableUS flag
Complete Lice TreatmentPyrethrum extract (0.33 g/100mL) + Piperonyl butoxide (4 g/100mL)KitTopicalMeijer Distribution2007-09-122015-10-01US flag
CVS 3 Step Lice SolutionPyrethrum extract (3.3 mg/1mL) + Piperonyl butoxide (40 mg/1mL)KitTopicalCVS2010-10-28Not applicableUS flag
CVS Health Lice KillingPyrethrum extract (0.33 g/100mL) + Piperonyl butoxide (4 g/100mL)ShampooTopicalCVS Health2010-10-28Not applicableUS flag
Dg Health Lice Killing Maximum StrengthPyrethrum extract (0.33 g/100mL) + Piperonyl butoxide (4 g/100mL)ShampooTopicalDolgencorp2010-01-082012-08-18US flag

Categories

Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
ZUM06L90GV
CAS number
8003-34-7

References

General References
Not Available
PubChem Substance
347911110
RxNav
1232405

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
RinseTopical
LiquidTopical
ShampooTopical0.3 %
Aerosol; shampooTopical
KitTopical
OilTopical
GelTopical
ShampooTopical
Liquid; shampooTopical
SolutionIntradermal; Percutaneous; Subcutaneous0.001 g/1mL
SolutionIntradermal; Percutaneous; Subcutaneous0.05 g/1mL
SolutionIntradermal; Percutaneous; Subcutaneous0.1 g/1mL
SolutionIntradermal; Percutaneous; Subcutaneous20000 [PNU]/1mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism an...
Gene Name
NR1I2
Uniprot ID
O75469
Uniprot Name
Nuclear receptor subfamily 1 group I member 2
Molecular Weight
49761.245 Da
References
  1. Kojima H, Sata F, Takeuchi S, Sueyoshi T, Nagai T: Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb 27;280(3):77-87. doi: 10.1016/j.tox.2010.11.008. Epub 2010 Nov 27. [PubMed:21115097]

Drug created on December 03, 2015 09:51 / Updated on June 12, 2020 11:42

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