This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Pyrethrum extract is a chrysanthemum flower extract used to treat head, pubic, and body lice.
- Brand Names
- Pronto Plus, Rid
- Generic Name
- Pyrethrum extract
- DrugBank Accession Number
- DB11087
- Background
Pyrethrum is the crude extract form obtained from flowers of the plant Chrysanthemum cinerariifolium. Pyrethrin refers to a more refined extract of pyrethrum. While pyrethrum extract is composed of 6 esters, both organic compounds mediate insecticidal activities. Pyrethrum-containing mixtures are used as a common insecticide to control specific pest species. Pyrethrum extract is also used used to treat head, body, and pubic lice infections. The active compound is absorbed by the lice and destroys them by acting on their nervous systems but is thought to exert minimal effect on humans.
- Type
- Biotech
- Groups
- Approved
- Biologic Classification
- Allergenics
Allergen Extract - Synonyms
- Allergenic extract, pyrethrum
- Chrysanthemum cinerariifolium pyrethrins extract
- Pyrethrins
- Pyrethrins and pyrethroids
- Pyrethrins component of rid mousse
- Pyrethrum
- Pyrethrum extract
- Pyrethrum oleo resin
- Pyrethrum oleoresin
- Rid mousse component pyrethrins
- Tanacetum cinerariifolium pyrethrins extract
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UNuclear receptor subfamily 1 group I member 2 Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Pyrethrum Solution 20000 [PNU]/1mL Intradermal; Percutaneous; Subcutaneous Greer Laboratories, Inc. 1981-09-15 Not applicable US 
Pyrethrum Solution 0.1 g/1mL Intradermal; Percutaneous; Subcutaneous Greer Laboratories, Inc. 1981-09-15 Not applicable US Pyrethrum Solution 0.05 g/1mL Intradermal; Percutaneous; Subcutaneous Greer Laboratories, Inc. 1981-09-15 Not applicable US Pyrethrum Solution 0.001 g/1mL Intradermal; Percutaneous; Subcutaneous Greer Laboratories, Inc. 1981-09-15 Not applicable US - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Mosquitoes Prevent Liquid 0.01 kg/1kg Topical Jiangsu New Reba Technology Inc. 2022-12-21 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Best Choice Lice Killing Pyrethrum extract (0.33 g/100mL) + Piperonyl butoxide (4 g/100mL) Shampoo Topical Value Merchandisers 2010-10-28 Not applicable US Best Choice Lice treatment Pyrethrum extract (3.3 mg/1mL) + Piperonyl butoxide (40 mg/1mL) Kit Topical Value Merchandisers 2010-10-28 Not applicable US Care One Lice Killing Pyrethrum extract (0.33 g/100mL) + Piperonyl butoxide (4 g/100mL) Shampoo Topical American Sales Company 2007-08-29 Not applicable US Careone Complete Kit Lice Pyrethrum extract (.33 g/100mL) + Piperonyl butoxide (4 g/100mL) Kit Topical American Sales Company 2019-01-26 Not applicable US Careone Lice Pyrethrum extract (0.33 g/100mL) + Piperonyl butoxide (4 g/100mL) Kit; Shampoo Topical American Sales Company 2007-09-26 2013-10-28 US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- ZUM06L90GV
- CAS number
- 8003-34-7
References
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Rinse Topical Liquid Topical Kit; shampoo Topical Aerosol; shampoo Topical Kit Topical Oil Topical Gel Topical Shampoo Topical Liquid Topical 0.01 kg/1kg Liquid; shampoo Topical Solution Intradermal; Percutaneous; Subcutaneous 0.001 g/1mL Solution Intradermal; Percutaneous; Subcutaneous 0.05 g/1mL Solution Intradermal; Percutaneous; Subcutaneous 0.1 g/1mL Solution Intradermal; Percutaneous; Subcutaneous 20000 [PNU]/1mL Solution Topical - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism an...
- Gene Name
- NR1I2
- Uniprot ID
- O75469
- Uniprot Name
- Nuclear receptor subfamily 1 group I member 2
- Molecular Weight
- 49761.245 Da
References
- Kojima H, Sata F, Takeuchi S, Sueyoshi T, Nagai T: Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb 27;280(3):77-87. doi: 10.1016/j.tox.2010.11.008. Epub 2010 Nov 27. [Article]
Drug created at December 03, 2015 16:51 / Updated at February 21, 2021 18:52