Nuclear receptor subfamily 1 group I member 2

BE0000956ProteinHumansNR1I2

Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. It is acted on by 82 drugs in DrugBank.

Gene name
NR1I2
UniProtKB entry
O75469Swiss-Prot
Cellular location
Nucleus
Residues / weight
434 residues · 49,761 Da
Also known as
Orphan nuclear receptor PAR1 · Orphan nuclear receptor PXR · Pregnane X receptor · PXR · Steroid and xenobiotic receptor

Resolves to

Protein
UniProtO75469UniProt nameNR1I2_HUMAN
Gene
HGNCHGNC:7968NCBI Gene8856GenBank3511138GeneCardsNR1I2
Pharmacology
IUPHAR/GtoPdb606KEGGhsa:8856
Structure
PDB1ILGPDB1ILHPDB1M13
Drugs

What you can answer from here — as of September 07, 2019

82DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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18GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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124+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nuclear receptor subfamily 1 group I member 2, how selective are they, and which programs against it are still in active trials?

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